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首页> 外文期刊>British Journal of Cancer >Immunogenicity and Immunosensitivity of Urethane-induced Murine Lung Adenomata, in Relation to the Immunological Impairment of the Primary Tumour Host
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Immunogenicity and Immunosensitivity of Urethane-induced Murine Lung Adenomata, in Relation to the Immunological Impairment of the Primary Tumour Host

机译：尿烷诱导的鼠肺腺瘤的免疫原性和免疫敏感性与原发肿瘤宿主的免疫功能障碍相关

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摘要

The depression of the immunological status of BALB/c mice treated during infancy with two different doses of urethane, alone or combined with cortisone, was evaluated by counting the number of plaque forming cells at 30 or 50 days of age. The incidence of lung adenomatous nodules was directly related to the degree of immunological impairment at 50 days of age. Twenty-seven lung adenomata were tested in an in vitro system involving spleen cells immune against the same single tumour used as target cell. Eighty-six per cent of tumours in the most immunodepressed group of mice were positive compared with 20-40% in the less immunodepressed groups. Syngeneic cross-reaction tests showed that non-immunogenic tumours were immunosensitive since 66% positive tests were obtained when target cells belonging to the less immunodepressed groups were tested with spleen cells of mice immunized with immunogenic adenomata.
机译：通过计算30或50天龄时形成斑块的细胞数量，评估了在婴儿期用两种不同剂量的尿烷（单独或与可的松联用）治疗的BALB / c小鼠的免疫学状况是否降低。肺腺瘤性结节的发生与50日龄时免疫功能受损的程度直接相关。在涉及脾脏细胞的体外系统中对二十七个肺腺瘤进行了测试，该脾脏细胞对用作靶细胞的同一单个肿瘤免疫。在免疫力最弱的小鼠组中，有86％的肿瘤是阳性的，而免疫力较弱的组的肿瘤为20-40％。同基因交叉反应测试显示非免疫原性肿瘤是免疫敏感性的，因为当用免疫原性腺瘤免疫的小鼠的脾细胞测试属于免疫抑制程度较低的组的靶细胞时，获得了66％的阳性测试。

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