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首页> 外文期刊>British Journal of Cancer >Cell-mediated Immunity and Antibodies to Herpesvirus hominis Type 1 in Oral Leukoplakia and Carcinoma
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Cell-mediated Immunity and Antibodies to Herpesvirus hominis Type 1 in Oral Leukoplakia and Carcinoma

机译：口腔白斑和癌的细胞介导的免疫和人疱疹病毒1型抗体。

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Cell-mediated and humoral immune responses to Herpesvirus hominis type 1 (HVH1) and Candida albicans were studied in patients with leukoplakia, showing a histological spectrum of changes from epithelial keratosis to acanthosis and atypia, and in patients with carcinoma. The results were ranked according to increasing values of stimulation indices of lymphocyte transformation to HVH1, and the corresponding macrophage migration inhibition indices, and complement fixing antibody titres of each patient were correlated. This revealed that most patients with epithelial atypia were clustered to that end of the spectrum which had the highest stimulation and migration indices to HVH1; this relationship was not evident with C. albicans. In patients with keratosis and acanthosis there was a significant lack of correlation between lymphocyte transformation and migration inhibition to both HVH1 and C. albicans. In carcinoma the indices of lymphocyte transformation and migration inhibition to HVH1 and C. albicans were depressed. Furthermore, a significant negative correlation was found between lymphocyte transformation and migration inhibition to HVH1, unlike the positive correlation in control subjects. Complement fixing antibodies to HVH1, HVH2, cytomegalovirus and adenovirus, and fluorescent antibodies to C. albicans failed to show a significant change in titre in any one group of subjects tested. The results suggest a cell-mediated immune defect in leukoplakia, with a dissociation between lymphocyte transformation and macrophage migration inhibition to HVH1 and C. albicans in cases of keratosis or acanthosis. A specific increase in cell-mediated immunity to HVH1 in leukoplakia with epithelial atypia and the sequential changes argue in favour of a possible participation of HVH1 in carcinomatous transformation of some leukoplakias.
机译：在白斑患者中研究了对人疱疹病毒1型（HVH1）和白色念珠菌的细胞介导和体液免疫反应，显示了从上皮角化病到棘皮症和非典型性以及癌症患者的组织学变化。根据淋巴细胞转化为HVH1的刺激指数的增加值对结果进行排名，并将相应的巨噬细胞迁移抑制指数与每个患者的补体固定抗体滴度进行关联。这表明，大多数上皮非典型患者聚集在频谱末端，从而刺激和迁移至HVH1指数最高。这种关系在白色念珠菌中并不明显。在患有角化病和棘皮症的患者中，淋巴细胞转化与对HVH1和白色念珠菌的迁移抑制之间显着缺乏相关性。在癌症中，淋巴细胞转化和向HVH1和白色念珠菌迁移抑制的指数降低。此外，与对照组相比，淋巴细胞转化与向HVH1的迁移抑制之间存在显着的负相关。针对HVH1，HVH2，巨细胞病毒和腺病毒的补体固定抗体，以及针对白色念珠菌的荧光抗体，在任何一组测试对象中均未显示出显着的滴度变化。结果表明，在角化或棘皮症的情况下，白斑的细胞介导的免疫缺陷与淋巴细胞转化和巨噬细胞向HVH1和白色念珠菌迁移的抑制作用解离。在具有上皮非典型性的白斑中细胞介导的对HVH1免疫力的特定增加和顺序变化表明，HVH1可能参与某些白斑的癌性转化。

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