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首页> 外文期刊>British Journal of Cancer >The detection by immunodiffusion of tumour associated antigenic components in extracts of human bronchogenic carcinoma
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The detection by immunodiffusion of tumour associated antigenic components in extracts of human bronchogenic carcinoma

机译：通过免疫扩散检测人支气管癌提取物中肿瘤相关抗原成分

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Antisera to extracts of a variety of bronchogenic carcinoma were raised in rabbits and extensively absorbed with immunoadsorbents prepared with normal lung extracts cyanogen bromide linked to Sepharose 4B, and glutaraldehyde insolubilized normal lung extracts. The antisera were tested by immunodiffusion against a panel of extracts from a variety of bronchogenic carcinoma, foetal lung extracts and pools of normal lung extracts. The results indicate that two distinct antigenic components are associated with bronchogenic carcinoma; one which is present in a high percentage of the tumour extracts tested and appears to have partial identity with a foetal lung component, and one (or more) which is not foetal and appears to have higher cross-reactivity (but not exclusively) with tumours of the same pathological type. Attempts to detect either antibody or antigens relating to these components in the serum of patients with bronchogenic carcinoma by these techniques were unsuccessful. The foetal cross-reacting component was neither carcinoembryonic antigen and alpha1-foetoprotein.
机译：在兔体内培养了针对多种支气管癌提取物的抗血清，并被正常肺提取物与琼脂糖4B连接的溴化氰和戊二醛不溶性正常肺提取物制备的免疫吸附剂广泛吸收。通过对一组来自各种支气管癌的提取物，胎儿肺提取物和正常肺提取物库进行免疫扩散来测试抗血清。结果表明，两种不同的抗原成分与支气管癌有关。一种存在于所测试的肿瘤提取物中的百分比很高，并且似乎与胎儿的肺成分具有部分同一性，一种（或多种）不是胎儿的并且似乎与肿瘤具有更高的交叉反应性（但不仅限于此）具有相同的病理类型。通过这些技术尝试检测支气管癌患者血清中与这些成分有关的抗体或抗原均未成功。胎儿的交叉反应成分既不是癌胚抗原也不是α1-叶酸蛋白。

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