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首页> 外文期刊>British Journal of Cancer >Non-protein bound oestradiol, sex hormone binding globulin, breast cancer and breast cancer risk
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Non-protein bound oestradiol, sex hormone binding globulin, breast cancer and breast cancer risk

机译：非蛋白结合雌二醇，性激素结合球蛋白，乳腺癌和罹患乳腺癌的风险

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It has recently been found by various authors that despite a normal serum concentration of oestradiol (E2), the percentage of non-protein-bound or free E2 is abnormally high in breast cancer patients. Since it is the free E2 which is considered to be biologically active, confirmation of this finding would be most relevant to the pathogenesis of breast cancer. Using Hammond's centrifugal ultrafiltration dialysis method we have measured free E2 in heparinized plasma from 68 premenopausal women (a) at high familial risk of breast cancer (n = 18), (b) with benign breast disease (n = 17), (c) cured of T1N0M0 breast cancer at least 6 months previously (n = 17) and (d) normal controls matched for age, parity and Quetelet index (n = 16). Sex hormone binding globulin (SHBG) was measured as [3H]-dihydrotestosterone binding capacity. Free E2 and SHBG were also measured in the serum of (e) postmenopausal patients having breast cancer (n = 38) and (f) matched control cancer patients (n = 67). We confirmed a very good inverse correlation between log free E2 per cent and log SHBG (P less than 0.0001). The regression lines for groups (a)-(d) were not statistically different. The regression lines for groups (e) and (f) were identical and ran nearly parallel to those for groups (a)-(d) though somewhat lower. This small difference may be ascribed to menopausal status. Therefore, we found no difference in free E2 percentage, calculated free E2 concentration or SHBG between premenopausal women at risk, women with benign breast disease, patients cured for early breast cancer or having breast cancer and matched controls. However, postmenopausal breast cancer patients had a significantly higher total serum E2 concentration and, by consequence a higher calculated free E2 concentration compared to the carefully matched control group.
机译：最近，各种作者发现，尽管雌二醇（E2）的血清浓度正常，但乳腺癌患者中非蛋白结合或游离E2的百分比异常高。由于游离E2被认为具有生物活性，因此对该发现的确认与乳腺癌的发病机理最相关。使用Hammond的离心超滤透析方法，我们测量了68位绝经前妇女（a）患乳腺癌的家族性高风险（n = 18），（b）乳腺良性疾病（n = 17），（c）肝素化血浆中的游离E2。至少在6个月前治愈了T1N0M0乳腺癌（n = 17），并且（d）年龄，胎次和Quetelet指数匹配的正常对照组（n = 16）。性激素结合球蛋白（SHBG）测定为[3H]-二氢睾丸激素的结合能力。还测量了（e）绝经后患有乳腺癌的患者（n = 38）和（f）匹配的对照癌症患者（n = 67）的血清中游离E2和SHBG。我们确认了对数自由E2％与对数SHBG之间有很好的逆相关性（P小于0.0001）。 （a）-（d）组的回归线在统计上没有差异。 （e）和（f）组的回归线相同，并且与（a）-（d）组的回归线几乎平行，但略低。这种小的差异可能归因于更年期状态。因此，我们发现处于危险中的绝经前妇女，患有良性乳腺疾病的妇女，已治愈早期乳腺癌或患有乳腺癌的患者以及匹配的对照组之间的游离E2百分比，计算的游离E2浓度或SHBG均无差异。但是，绝经后乳腺癌患者的血清总E2浓度明显高于对照组，因此其游离E2的计算浓度较高。

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