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首页> 外文期刊>British Journal of Cancer >Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver
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Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver

机译：肝转移的低水平直接电流疗法。一，正常肝脏的临床前研究

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Low-level direct electrical current has shown promise as a potential therapeutic modality (direct current therapy; DCT) in the treatment of malignant disease, including metastases, but to date much experimental work has been empirical and has added little to our knowledge of the mechanisms involved. As a prerequisite to a clinical trial for metastases in the liver, we have employed an in vivo liver model to examine the quantitative and qualitative relationships between electrode polarity, charge and tissue necrosis. Two distinct regions of necrosis were induced, distinguishable histologically and by magnetic resonance imaging: (i) a cylindrical region of primary necrosis centred on the electrode, its volume directly proportional to the charge passed, but greater at the anode than cathode; and (ii) a wedge-shaped infarct, apex at the electrode and base extending to the liver edge. The extent of this infarct was again greater at the anode than the cathode, but showed a sigmoidal relationship with charge. Results indicate pH changes at the electrodes as likely mediators of tissue injury, but show also that significant distant ischaemic injury can occur as a consequence of primary damage. These findings should be considered when selecting tumours for possible direct current therapy and when determining the sites of electrode placement.
机译：低电平直流电已被证明是治疗包括转移在内的恶性疾病的一种潜在治疗方式（直流电; DCT），但迄今为止，许多实验工作仍是凭经验进行的，对我们对该机制的了解很少参与。作为进行肝转移临床试验的先决条件，我们采用了体内肝脏模型来检查电极极性，电荷和组织坏死之间的定量和定性关系。通过组织学和磁共振成像可以区分出两个不同的坏死区域：（i）一个主要坏死的圆柱状区域，其中心位于电极上，其体积与通过的电荷成正比，但在阳极大于阴极。 （ii）楔形梗塞，在电极和基部的顶点延伸到肝边缘。该梗塞的程度在阳极处再次大于阴极，但显示出与电荷呈S形关系。结果表明，电极处的pH值变化可能是组织损伤的介质，但也表明，原发性损伤可能导致明显的远处缺血性损伤。在选择可能进行直流治疗的肿瘤以及确定电极放置部位时，应考虑这些发现。

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