Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

AC Lambrechts; LHJ Looijenga; MB vant Veer; J van Echten; W Timens; JW Oosterhuis

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Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

机译：睾丸局部淋巴瘤显示一致的BCL-2表达而无移位（14; 18）：分子和免疫组化研究

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The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

机译：BCL-2蛋白的存在在睾丸定位的9例非霍奇金淋巴瘤中进行了研究。发现一致存在的BCL-2蛋白。既没有通过细胞遗传学分析（n = 4），也没有通过聚合酶链反应扩增和Southern印迹（n = 9）观察到染色体易位（14; 18）。因此，这种移位不负责睾丸定位的非霍奇金淋巴瘤中BCL-2蛋白的存在。我们建议这些淋巴瘤中BCL-2蛋白的存在与B淋巴细胞的分化阶段有关，或者可能在这些淋巴瘤的发病机理中起作用。在睾丸局部定位的淋巴瘤中BCL-2蛋白的一致发现可能支持这些淋巴瘤是独立实体的临床观察。

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《British Journal of Cancer》 |1995年第1期|共5页
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AC Lambrechts; LHJ Looijenga; MB vant Veer; J van Echten; W Timens; JW Oosterhuis;
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中图分类肿瘤学;
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1. A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression. [J] . Chang CM, Schroeder JC, Olshan AF, Cancer causes and control: CCC . 2010,第7期

机译：一项病例对照研究，研究烟草使用和其他由t（14; 18）易位和bcl-2表达定义的淋巴瘤亚型的非职业危险因素。
2. A case–control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression [J] . Cindy M. Chang, Jane C. Schroeder, Andrew F. Olshan, Cancer Causes and Control . 2010,第7期

机译：由t（14; 18）易位和bcl-2表达定义的烟草使用和其他非职业性淋巴瘤亚型危险因素的病例对照研究
3. Molecular Evaluation of t(14;18)(bcl-2/IgH) Translocation in Follicular Lymphoma at Diagnosis Using Paraffin-Embedded Tissue Sections [J] . Nur Selvi, Buket Kosova, Mine Hekimgil, Turkish Journal of Hematology . 2012,第2期

机译：使用石蜡包埋组织切片诊断滤泡性淋巴瘤中t（14; 18）（bcl-2 / IgH）易位的分子评估
4. MOLECULAR IMAGING OF THE BCL-2 ONCOGENE IN CANINE B-CELL LYMPHOMA [C] . Kimberly A Statham, Micheal R Lewis, Jonathan A Green, Annual conference of the Veterinary Cancer Society . 2008

机译：犬B细胞淋巴瘤BCL-2癌基因的分子成像
5. Fluorescence in situ hybridization (FISH) and risk factors for non-Hodgkin lymphoma (NHL) subtypes defined by t(14;18) translocations and bcl-2 expression. [D] . Chang, Cindy Ma. 2007

机译：荧光原位杂交（FISH）和非霍奇金淋巴瘤（NHL）亚型的危险因素，定义为t（14; 18）易位和bcl-2表达。
6. Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study. [O] . A. C. Lambrechts, L. H. Looijenga, M. B. vant Veer, 1995

机译：具有睾丸定位的淋巴瘤显示出一致的BCL-2表达而没有移位（14; 18）：一项分子和免疫组织化学研究。
7. Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study. [O] . Lambrechts, A. C., Looijenga, L. H., van't Veer, M. B., 1995

机译：具有睾丸定位的淋巴瘤显示出一致的BCL-2表达而没有移位（14; 18）：一项分子和免疫组织化学研究。

Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study

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