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首页> 外文期刊>British Journal of Cancer >The Growth of Human Tumours in Immunosuppressed Mice and Their Response to Chemotherapy
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The Growth of Human Tumours in Immunosuppressed Mice and Their Response to Chemotherapy

机译：免疫抑制小鼠中人肿瘤的生长及其对化学疗法的反应

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One hundred and sixteen human tumours were transplanted to thymectomized, irradiated, antilymphocyte serum-treated mice. In 12 cases the recipient mice died rapidly, presumably from infection. With the remaining 104 tumours, three-quarters grew to a varying extent, retaining the characteristic histological features of the primary tumours. Implant nodules varied widely in composition, from solid tumour and stroma to dense fibrous tissue without recognizable tumour cells. There was no relation between degree of malignancy and ability to grow, and also some benign tumours grew.In 44 cases, mice were treated with the drug or drugs most likely to be used in the patients and the effects on the implants were assessed histologically. Two tumours were largely destroyed and one showed marked metaphase arrest. Three other tumours showed lesser changes that were attributable to the drug but were of equivocal significance.There appeared to be differences in drug sensitivity between structurally different clones of the same tumour, and some tumours treated with two alkylating agents were damaged by one and not the other, suggesting that this model may have substantial discriminatory power. Assays such as this should not be used to guide treatment of the patient without prior validation. The practical and ethical difficulties of validation by clinical trial may be insurmountable, and an alternative approach to validation is proposed which does not raise these difficulties.
机译：116例人类肿瘤被移植到经胸腺切除，照射，抗淋巴细胞血清治疗的小鼠中。在12例病例中，受体小鼠迅速死亡，大概是由于感染引起的。在剩下的104种肿瘤中，四分之三增长到不同程度，保留了原发肿瘤的组织学特征。植入结节的成分变化很大，从实体瘤和间质到致密的纤维组织，无可辨认的肿瘤细胞。恶性程度与生长能力之间没有关系，也有一些良性肿瘤生长。在44例中，对小鼠进行了一种或多种最可能用于患者的药物治疗，并通过组织学评估了对植入物的影响。两种肿瘤被严重破坏，其中一种显示出明显的中期停滞。其他三个肿瘤表现出较少的变化，这可归因于药物但具有不明确的意义。在相同肿瘤的结构不同克隆之间，药物敏感性似乎存在差异，并且用两种烷化剂治疗的一些肿瘤被一种损伤而不是由两种烷基化剂损伤。另外，这表明该模型可能具有实质性的歧视能力。未经事先确认，不得使用此类方法指导患者治疗。通过临床试验进行验证的实践和伦理上的困难可能是无法克服的，因此提出了另一种验证方法，它不会引起这些困难。

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