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首页> 外文期刊>British Journal of Cancer >Horizontal studies of cell mediated immune reactions to autologous tumour antigens in patients with operable mammary carcinoma
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Horizontal studies of cell mediated immune reactions to autologous tumour antigens in patients with operable mammary carcinoma

机译：可手术的乳腺癌患者对自身肿瘤抗原的细胞介导免疫反应的水平研究

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摘要

The leucocyte migration and guinea-pig macrophage migration procedures were used to assess cell mediated, tumour directed immune reactions in patients with mammary carcinoma undergoing simple mastectomy with or without post-operative irradiation. Forty-seven per cent of patients reacted to autologous tumour antigens and 40% to allogeneic antigens when tested 7 days after operation; 23% reacted to autologous antigens at 2 months, 19% at 6 months and 34% at 1 year after surgery. Reactions to benign tissue fractions were rare. Better discrimination between test and control subjects was obtained when 3000 g sediments rather than nuclei-depleted homogenates (extracts) were used. Irradiation 3-7 weeks post-operatively did not depress the in vitro response at 2 months and yielded a higher rate of positive reactions at 6 months. Correlations of serial LMT responses with certain clinical findings are discussed.
机译：白细胞迁移和豚鼠巨噬细胞迁移程序用于评估接受或不接受术后单纯乳房切除术的乳腺癌患者的细胞介导的，肿瘤定向的免疫反应。术后7天进行测试时，有47％的患者对自体肿瘤抗原有反应，有40％的患者对同种异体抗原有反应。术后2个月有23％的患者对自体抗原有反应，术后6个月有19％的患者对自身抗原有反应，术后1年有34％的患者对自身抗原有反应。对良性组织部分的反应很少。当使用3000 g沉积物而不是去除核的匀浆（提取物）时，可以更好地区分测试对象和对照对象。术后3-7周照射在2个月时并未降低体外反应，在6个月时产生了更高的阳性反应率。讨论了一系列LMT反应与某些临床发现的相关性。

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