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首页> 外文期刊>British Journal of Cancer >Plasma CEA in the post-surgical monitoring of colorectal carcinoma
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Plasma CEA in the post-surgical monitoring of colorectal carcinoma

机译：血浆CEA在大肠癌术后监测中的应用

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This paper reports the findings of the M.R.C., study into the use of the plasma CEA test for early detection of recurrence following "successful" surgery for colorectal carcinoma. This study was set up in 1973, and represents the largest series of patients published on this topic. It was primarily prospective, 468 patients being entered at the time of, or after the initial diagnosis of colorectal carcinoma. Follow-up was for at least 2 years, and both initially and throughout the follow-up the clinician treating the patient was kept "blind" to the patient's plasma CEA level. The general conclusion is that the CEA test provides a useful additional tool for the early detection of recurrence in these patients. Sixty-five per cent of patients with recurrence showed a raised plasma CEA level, and over half the patients who developed recurrence had a raised level some time before the disease was detected by other means. A surprising number of patients had a raised CEA level on a single occasion which subsequently returned to normal at the next follow-up and did not seem to be associated with malignancy. The problems associated with this type of study and their limiting effect on interpretation are discussed.
机译：本文报道了M.R.C.的研究结果，研究了血浆CEA测试在大肠癌“成功”手术后早期发现复发中的应用。这项研究成立于1973年，代表了有关该主题的最大系列患者。主要是前瞻性的，在大肠癌初步诊断时或之后有468例患者入组。随访至少2年，在最初和整个随访过程中，治疗患者的临床医生均被“盲”至患者血浆CEA水平。总的结论是，CEA测试为早期检测这些患者的复发提供了有用的附加工具。 65％的复发患者显示血浆CEA水平升高，而超过一半的复发患者在通过其他手段检测出疾病之前的某个时间水平升高。令人惊讶的是，单次CEA水平升高的患者随后又在下一次随访中恢复正常，似乎与恶性肿瘤无关。讨论了与这类研究相关的问题及其对解释的限制作用。

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