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首页> 外文期刊>British Journal of Cancer >Induction of bladder cancer in rats by fractionated intravesicular doses of N-methyl-N-nitrosourea
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Induction of bladder cancer in rats by fractionated intravesicular doses of N-methyl-N-nitrosourea

机译：膀胱内分次给予N-甲基-N-亚硝基脲诱导大鼠膀胱癌

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摘要

Experiments were conducted to determine the dose response of rat bladder urothelium to a range of different single and fractionated intravesicular doses of the carcinogen, N-methyl-N-nitrosourea (MNU). A dose-related response of bladder-tumour incidence to single graded doses of MNU was found, and a threshold does suitable for use of multistage carcinogenesis experiments was derived from these data. For any given total dose of MNU, the tumour incidence was greater if the MNU had been administered in several small fractions than if it had been administered in fewer larger ones. Extending the interval between doses did not reduce the tumour incidence. It is argued that these results support the multistage theory of carcinogenesis. The histopathology and cell-surface alterations which characterize the development of MNU-induced bladder cancer are described and the contribution of hyperplasia and calculi are discussed.
机译：进行实验以确定大鼠膀胱尿路上皮对一系列不同的单个和分级囊内致癌物N-甲基-N-亚硝基脲（MNU）剂量的剂量反应。发现膀胱肿瘤发生率与MNU单次剂量的剂量相关反应，并且从这些数据中得出了适合用于多阶段致癌实验的阈值。对于任何给定的MNU总剂量，如果将MNU分成几小部分进行给药，则其肿瘤发生率要比如果以较小的大剂量进行给药的肿瘤发生率更高。延长剂量间隔不会降低肿瘤发生率。有人认为，这些结果支持多阶段的致癌理论。描述了以MNU诱导的膀胱癌发展为特征的组织病理学和细胞表面变化，并讨论了增生和结石的作用。

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