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首页> 外文期刊>British Journal of Cancer >Effect of C. Parvum on immunization with irradiated tumour cells
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Effect of C. Parvum on immunization with irradiated tumour cells

机译：细小衣原体对照射的肿瘤细胞免疫的影响

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S.c. injection of tumour cells or small pieces of tumour irradiated to a dose of 22,000 rad evoked resistance to live challenge with the same tumour (a CBA strain fibrosarcoma induced with methylcholanthrene) 14 days later. This resistance was, however, over-ridden if the challenging inoculum was sufficiently large, and did not develop if the cells were irradiated to 100,000 rad. The resistance evoked by injection of 10(6) irradiated tumour cells was impaired by i.p. injection of 1-4 mg C. parvum 5 days before, and virtually abolished by a similar injection 11 days after, the irradiated cells. The effect of s.c. injection of a mixture of 10(6) irradiated cells and C. parvum 14 days before live challenge depended on the dose of C. parvum. With 0-7 mg the development of resistance was largely but not completely abrogated; 0-35 mg resulted in a lesser degree of abrogation, and 0-09 mg or 0-02 mg had little or no effect.
机译：南卡罗来纳州14天后，注射2​​2,000拉德剂量的肿瘤细胞或一小块肿瘤引起的对同一个肿瘤（由甲基胆甾醇诱导的CBA纤维肉瘤）的活激发抗性。但是，如果具有挑战性的接种物足够大，则这种抗性会被克服，而如果将细胞照射到100,000 rad，则不会产生这种抗性。 i.p.损害了通过注射10（6）辐射的肿瘤细胞引起的抗药性。在第5天之前注射1-4 mg细小梭状芽胞杆菌，然后在经过照射的细胞之后第11天通过类似的注射几乎废除。 s.c.的影响活攻击前14天注射10（6）辐照细胞和小球藻的混合物取决于小球藻的剂量。当使用0-7 mg时，抗药性的产生在很大程度上但没有完全消除。 0-35 mg导致的废除程度较低，0-09 mg或0-02 mg的作用很小或没有作用。

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