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首页> 外文期刊>British Journal of Cancer >Multiple risk factors associated with arsenic-induced skin cancer: effects of chronic liver disease and malnutritional status
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Multiple risk factors associated with arsenic-induced skin cancer: effects of chronic liver disease and malnutritional status

机译：与砷引起的皮肤癌相关的多种危险因素：慢性肝病和营养不良状况的影响

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In order to evaluate the prevalence and multiple risk factors of arsenic-induced skin cancer among residents in Taiwanese villages in which chronic arseniasis is hyperendemic, a total of 1571 subjects aged 30 or more years were recruited between September 1988 and March 1989. All of them were interviewed personally by a public health nurse using a structured questionnaire, and 1081 interviewed study subjects, including 468 men and 613 women, participated in physical examination, giving a participation rate of 68.8%. The overall prevalence of skin cancer was as high as 6.1%, showing an increase with age in both men and women. There was a significant dose-response relation between skin cancer prevalence and chronic arsenic exposure as indexed by duration of residence in the endemic area, duration of consumption of high-arsenic artesian well water, average arsenic exposure in parts per million (p.p.m.) and cumulative arsenic exposure in p.p.m.-years. Chronic carriers of hepatitis B surface antigen with liver dysfunction had an increased prevalence of skin cancer. Undernourishment, indexed by a high consumption of dried sweet potato as a staple food, was also significantly associated with an increased prevalence of arsenic-induced skin cancer. All these risk factors remained statistically significant in the multiple logistic regression analysis. Consistent with animal experiments, the findings imply that liver function and nutritional status may affect the metabolism of inorganic arsenic and the development of subsequent skin cancers.
机译：为了评估在慢性砷中毒高流行的台湾村居民中砷诱发的皮肤癌的患病率和多种危险因素，1988年9月至1989年3月，共招募了1571名年龄在30岁以上的受试者。接受公共卫生护士亲自使用结构化问卷进行了访谈，对1081名受访受试者（包括468名男性和613名女性）进行了身体检查，参与率为68.8％。皮肤癌的总体患病率高达6.1％，男女均随年龄增长而增加。皮肤癌患病率与慢性砷暴露之间存在显着的剂量反应关系，该关系由在流行区的停留时间，高砷自流井水的消耗时间，平均砷暴露量（百万分之一（ppm））和累积量来表示砷暴露，以ppm-年为单位。具有肝功能障碍的乙型肝炎表面抗原的慢性携带者皮肤癌的患病率增加。营养不足，主要由干红薯作为主食而引起，也与砷引起的皮肤癌的患病率增加显着相关。在多元逻辑回归分析中，所有这些风险因素在统计学上仍然显着。与动物实验一致，该发现暗示肝脏功能和营养状况可能影响无机砷的代谢以及随后的皮肤癌的发展。

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