Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse

J A Levy; A C White; C M McGrath

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Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse

机译：人乳腺癌细胞系在无胸腺小鼠不同部位的生长和组织学

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Experiments were conducted to determine whether the histological pattern of tumour growth of hormone-responsive MCF-7 human mammary adenocarcinoma varied in different tissues of athymic mice. Tumours in the uterus following intrauterine injection were rapidly proliferating and highly invasive. Tumours injected intracerebrally were also highly invasive. In contrast, s.c. tumours and those which arose in the lung following intrapleural injection, grew as small localized nodules without evidence of aggressive invasion of surrounding tissues. These findings indicate that selective implantation of human tumours in athymic mice can be used to develop different models of tumour growth and aggressiveness.

机译：进行实验以确定在无胸腺小鼠的不同组织中激素反应性MCF-7人乳腺腺癌的肿瘤生长的组织学模式是否发生变化。子宫内注射后子宫内的肿瘤正在迅速扩散并具有高度侵袭性。脑内注射的肿瘤也是高度侵入性的。相比之下，肿瘤以及胸膜内注射后在肺中产生的肿瘤，生长成小的局部结节，而没有侵袭周围组织的迹象。这些发现表明，在无胸腺小鼠中选择性植入人肿瘤可用于开发不同的肿瘤生长和侵袭性模型。

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《British Journal of Cancer》 |1982年第3期|共9页
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J A Levy; A C White; C M McGrath;
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中图分类肿瘤学;
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6. Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse. [O] . J. A. Levy, A. C. White, C. M. McGrath 1982

机译：人乳腺癌细胞系在无胸腺小鼠中不同部位的生长和组织学。
7. Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse. [O] . Levy, J. A., White, A. C., McGrath, C. M. 1982

机译：人乳腺癌细胞系在无胸腺小鼠中不同部位的生长和组织学。
8. Interaction of Dietary Genistein, Equol, and Aromatase Inhibitors on Growth of Estrogen-Dependent Human Breast Cancer (MCF-7Ca) Cell in Athymic Mice [R] . Chen, M. 2004

机译：膳食染料木黄酮，雌马酚和芳香酶抑制剂对无胸腺小鼠雌激素依赖性人乳腺癌（mCF-7Ca）细胞生长的影响

Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse

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