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首页> 外文期刊>British Journal of Cancer >Participation of polymorphonuclear leukocyte-derived factor in murine tumour cell killing
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Participation of polymorphonuclear leukocyte-derived factor in murine tumour cell killing

机译：多形核白细胞衍生因子参与鼠肿瘤细胞杀伤

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Previous studies showed that murine polymorphonuclear leukocytes (PMNs) lyze tumour cells in the presence of wheat germ agglutinin or actinomycin D. This paper reports studies on whether a soluble factor participates in PMN-mediated cytolysis dependent on lectin or a chemotherapeutic drug. Tumour lysis was observed with supernatants from PMN cocultured with wheat germ agglutinin or actinomycin D. The supernatant from cultures of PMNs alone was not cytotoxic, but addition of these agents to the supernatant induced tumour lysis. PMNs released a soluble factor spontaneously into the medium and cytolysis was induced by a combination of this factor and wheat germ agglutinin or actinomycin D. This factor was not an oxygen metabolite, but a protein with a molecular weight of approximately 100 K daltons. These results suggest that a soluble factor(s) from PMNs participates in tumour killing in cooperation with appropriate reagents.
机译：先前的研究表明，在存在小麦胚芽凝集素或放线菌素D的情况下，鼠多形核白细胞（PMN）会裂解肿瘤细胞。本文报道了关于可溶性因子是否参与依赖于凝集素或化疗药物的PMN介导的细胞溶解的研究。在与小麦胚芽凝集素或放线菌素D共培养的PMN上清液中观察到肿瘤溶解。单独PMNs培养物的上清液没有细胞毒性，但是将这些试剂添加到上清液中会诱导肿瘤溶解。 PMNs自发地将可溶性因子释放到培养基中，并通过该因子与小麦胚芽凝集素或放线菌素D的组合诱导细胞溶解。该因子不是氧代谢产物，而是分子量约为100 K道尔顿的蛋白质。这些结果表明，来自PMN的可溶性因子与适当的试剂合作参与了肿瘤的杀死。

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