Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG

M A Wainberg; V Deutsch; D W Weiss

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Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG

机译：卡介苗甲醇提取残留物刺激豚鼠的抗肿瘤免疫力

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The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis.

机译：在注射了可移植的二乙基亚硝胺诱导的10号肝细胞的细胞中，在菌株2的豚鼠中研究了BCG甲醇提取残基（MER）的免疫预防作用。在肿瘤植入前18到182天的时间进行MER预处理可以保护大约40％的豚鼠免于进行性肿瘤性疾病。此外，与未经MER处理的荷瘤对照相比，经MER处理的动物更快速且以更高的水平发展了特异性细胞介导的抗肿瘤免疫。但是，不可能从此类实验室研究的结果预测免疫预防的结果。

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《British Journal of Cancer》 |1976年第5期|共9页
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M A Wainberg; V Deutsch; D W Weiss;
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中图分类肿瘤学;
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1. Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG [J] . M A Wainberg, V Deutsch, D W Weiss British Journal of Cancer . 1976,第5期

机译：卡介苗甲醇提取残留物刺激豚鼠的抗肿瘤免疫力
2. A preliminary study of intravenous methanol extraction residue of BCG in treatment of advanced cancer [J] . E Robinson, A Bartal, J Honigman, British Journal of Cancer . 1977,第3期

机译：卡介苗静脉提取甲醇残余物治疗晚期癌症的初步研究
3. A preliminary study of intravenous methanol extraction residue of BCG in treatment of advanced cancer [J] . E Robinson, A Bartal, J Honigman, British Journal of Cancer . 1977,第3期

机译：卡介苗静脉提取甲醇残余物治疗晚期癌症的初步研究
4. Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity against Mycobacterium tuberculosis. [C] . Charles B. Chesson, Rebecca J. Nusbaum, Matt Huante, Society for Biomaterials annual meeting and exposition . 2018

机译：纳米级肽的自组装增强了BCG引发的针对结核分枝杆菌的细胞免疫。
5. Low dose BCG vaccination in mice: Immune responses and implications for tuberculosis control [D] . Gebreyohannes, Tadele K. 2007

机译：小鼠低剂量卡介苗接种：免疫反应及其对结核病控制的意义
6. Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG. [O] . M. A. Wainberg, V. Deutsch, D. W. Weiss 1976

机译：BCG的甲醇提取残留物刺激豚鼠的抗肿瘤免疫力。
7. Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG. [O] . Wainberg, M. A., Deutsch, V., Weiss, D. W. 1976

机译：BCG的甲醇提取残留物刺激豚鼠的抗肿瘤免疫力。
8. Low-Dose Priming Before Vaccination with the Phase I Chloroform- Methanol Residue Vaccine Against Q Fever Enhances Humoral and Cellular Immune Responses to Coxiella Burnetii [R] . Waag, D. M., England, M. J., Bolt, C. R., 2008

机译：用I期氯仿 - 甲醇残留疫苗接种针对Q热的疫苗接种前的低剂量引发增强了对Coxiella Burnetii的体液和细胞免疫应答

Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG

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