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首页> 外文期刊>British Journal of Cancer >Leukaemogenic action of phorbol in intact and thymectomized mice of different strains
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Leukaemogenic action of phorbol in intact and thymectomized mice of different strains

机译：佛波醇在完整和经胸腺切除的不同品系小鼠中的白血病生成作用

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Phorbol, the unesterified parent alcohol of the skin promoter TPA, was administered i.p., twice weekly, throughout the lifetime of mice of 7 inbred strains: males and females of AKR/J, C3Heb and BALB/c, and females of SJL/J, DBA/2, SWR and C57BL. A striking difference in strain response was observed, with a pronounced leukaemogenic effect in SWR, a signficiant shortening of the latent period for spontaneous reticulum cell sarcomas (RCNB) in SJL/J, and no demonstrable effect in the other strains. When mice of 3 of the above-mentioned strains (SWR, SJL/J and AKR/J) were thymectomized prior to the beginning of phorbol treatment, different patterns of response were again observed. Thymectomy did not influence the leukaemia incidence in SWR mice, slightly inhibited RCNB development in SJL/J mice and converted phorbol into a leukaemogenic agent for AKR/J mice.
机译：在7种近交系小鼠的一生中，每周两次腹腔注射phobbol（皮肤促进剂TPA的未酯化母体醇）：AKR / J，C3Heb和BALB / c的雄性和雌性以及SJL / J的雌性， DBA / 2，SWR和C57BL。观察到菌株反应的显着差异，在SWR中具有明显的白细胞生成作用，在SJL / J中自发性网状细胞肉瘤（RCNB）的潜伏期显着缩短，在其他菌株中没有明显的作用。在开始佛波醇治疗之前，对上述3种品系（SWR，SJL / J和AKR / J）的小鼠进行胸腺切除术时，再次观察到了不同的反应模式。胸腺切除术不影响SWR小鼠的白血病发病率，略微抑制SJL / J小鼠的RCNB发育，并将佛波醇转变为AKR / J小鼠的白血病生成剂。

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