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首页> 外文期刊>British Journal of Cancer >The effect of C3H mouse mammary tumour on the levels of serum and urine analytes in vivo
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The effect of C3H mouse mammary tumour on the levels of serum and urine analytes in vivo

机译：C3H小鼠乳腺肿瘤对体内血清和尿液分析物水平的影响

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A study of C3H mice implanted with mammary tumours has shown that the levels of serum total protein, alanine transaminase and alkaline phosphatase are all lower than those found in normal mice, while aspartate transaminase is higher. Serum urea values were similar to normal levels, but creatinine was lower in males and higher in females. In the male mice, urine protein and urine N-acetyl-beta-D-glucosaminidase (NAG) activity were lower than in normal mice. Comparisons were made with age and sex matched controls which was found to be important for alkaline phosphatase, as this was shown to decrease with increasing age of the mice over the period from 10-30 weeks of age. The analyte values found in this study provide useful base-line data for assessing biochemical toxicity of cancer chemotherapy agents. It has been shown that some of these values can vary with age, or can be different if tumour-bearing mice are used instead of normal mice.
机译：对植入了乳腺肿瘤的C3H小鼠的研究表明，血清总蛋白，丙氨酸转氨酶和碱性磷酸酶的水平均低于正常小鼠，而天冬氨酸转氨酶则较高。血清尿素值与正常水平相似，但肌酐在男性中较低，在女性中较高。在雄性小鼠中，尿蛋白和尿N-乙酰基-β-D-氨基葡萄糖苷酶（NAG）活性低于正常小鼠。与年龄和性别相匹配的对照进行了比较，发现该对照对于碱性磷酸酶很重要，因为在10至30周龄期间，随着小鼠年龄的增长，碱性磷酸酶会降低。这项研究中发现的分析物值为评估癌症化学治疗剂的生化毒性提供了有用的基准数据。已经显示这些值中的一些可以随年龄变化，或者如果使用荷瘤小鼠代替正常小鼠则可以不同。

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