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首页> 外文期刊>British Journal of Cancer >Laser-induced fluorescence studies of meso-tetra(hydroxyphenyl)chlorin in malignant and normal tissues in rats
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Laser-induced fluorescence studies of meso-tetra(hydroxyphenyl)chlorin in malignant and normal tissues in rats

机译：大鼠恶性和正常组织中细四（羟苯基）二氢卟酚的激光诱导荧光研究

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摘要

meso-Tetra(hydroxyphenyl)chlorin (mTHPC) is an attractive second-generation dihydroporphyrin photosensitiser for use in photodynamic therapy. In this study, 1.3 mg kg-1 body weight mTHPC was administered intravenously, and laser-induced fluorescence was used to characterise and compare its localisation and retention in different rat tissues, including an induced experimental adenocarcinoma, 24 h and 48 h post injection. These studies were performed in an attempt to predict the anatomical locations where mTHPC PDT might be most effective and suggest suitable injection--irradiation intervals in each case. Of particular interest were the intra-abdominal and intrathoracic tissues. The fluorescence was induced at 405 nm and the fluorescence spectrum in the region 450-750 nm was analysed. All collected spectra were dominated by the fluorescence signature of mTHPC with its peak at 652 nm, and all values in this study are in terms of background-free drug-specific fluorescence intensity at that wavelength. The photosensitiser accumulated in high concentrations in the tumour and the reticuloendothelial system. Muscular organs, such as the heart and the abdominal wall, were characterised by a low drug fluorescence signature.
机译：中四（羟苯基）二氢卟酚（mTHPC）是一种有吸引力的第二代二氢卟啉光敏剂，用于光动力疗法。在这项研究中，静脉注射1.3 mg kg-1体重的mTHPC，并在注射后24 h和48 h用激光诱导的荧光表征和比较其在不同大鼠组织（包括诱导的实验性腺癌）中的定位和保留。进行这些研究的目的是预测mTHPC PDT可能最有效的解剖位置，并建议每种情况下合适的注射-照射间隔。特别感兴趣的是腹内和胸内组织。在405nm处诱导荧光，并分析450-750nm区域中的荧光光谱。所有收集的光谱均以mTHPC的荧光特征为主，其峰值在652 nm，该研究中的所有值均以该波长下无背景的药物特异性荧光强度表示。光敏剂以高浓度积累在肿瘤和网状内皮系统中。诸如心脏和腹壁之类的肌肉器官的特征在于低的药物荧光特征。

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