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首页> 外文期刊>British Journal of Cancer >DNA ploidy and S-phase fraction as prognostic factors in patients with uveal melanomas
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DNA ploidy and S-phase fraction as prognostic factors in patients with uveal melanomas

机译：DNA倍性和S期分数作为葡萄膜黑色素瘤患者的预后因素

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In 96 patients with uveal malignant melanomas the tumours were investigated by DNA flow cytometry. Thirty-eight per cent of the melanomas were aneuploid. By univariate analysis significant correlations with survival were found for histological type, tumour size, DNA ploidy, evidence of 'blind eye' and S-phase fraction. By multivariate analysis, significant prognostic variables were found to be histological type (P = 0.0008), tumour size (P < 0.0001) and DNA ploidy (P = 0.0038). Evidence of 'blind eye' was not significantly correlated with survival after adjustments for the other variables mentioned above. The S-phase fraction could be estimated in all 60 diploid tumours and in 12 of 36 aneuploid melanomas. By univariate analysis this variable was found to be a significant prognostic factor, but did not remain so after adjustment for ploidy, histological type and tumor size. We further conclude that patients with small DNA diploid uveal melanomas of spindle cell type have a rather favourable prognosis.
机译：通过DNA流式细胞术检查了96例葡萄膜恶性黑色素瘤患者的肿瘤。 38％的黑色素瘤是非整倍体。通过单变量分析，发现组织学类型，肿瘤大小，DNA倍性，“盲目”证据和S期分数与生存率显着相关。通过多变量分析，发现明显的预后变量为组织学类型（P = 0.0008），肿瘤大小（P <0.0001）和DNA倍性（P = 0.0038）。调整上述其他变量后，“盲目”证据与生存率无显着相关性。可以在所有60个二倍体肿瘤和36个非整倍性黑素瘤中的12个中估计S期分数。通过单变量分析，发现该变量是重要的预后因素，但在调整了倍性，组织学类型和肿瘤大小后，该变量并未保留。我们进一步得出结论，梭形细胞型小DNA二倍体葡萄膜黑色素瘤患者预后较好。

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