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首页> 外文期刊>British Journal of Cancer >Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients
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Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients

机译：与安慰剂相比，布洛芬可降低胰腺癌患者的能量消耗和急性期蛋白的产生

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The aim of this study was to investigate the effect of the cyclo-oxygenase inhibitor ibuprofen on the acute-phase protein response and resting energy expenditure (REE) of weight-losing patients with pancreatic cancer. Patients with irresectable pancreatic cancer (n = 16) were treated with either ibuprofen (1200 mg day-1 for 7 days (n = 10) or placebo (n = 6). A group of 17 age-related non-cancer subjects were also studied. Indirect calorimetry, anthropometry, multifrequency bioelectrical impedence analysis and serum C-reactive protein (CRP) estimation were performed immediately before and after treatment. Before treatment, total REE was significantly elevated in the pancreatic cancer patients compared with healthy controls (1499 +/- 71 vs 1377 +/- 58 kcal) (P < 0.02). Following treatment the mean REE of the ibuprofen group fell significantly (1386 +/- 89 kcal) compared with pretreatment values (1468 +/- 99 kcal) (P < 0.02), whereas no change was observed in the placebo group. Serum CRP concentration was also reduced in the ibuprofen-treated group (pre-ibuprofen, 51 mg l-1; post-ibuprofen, 29 mg l-1; P < 0.05). These results suggest that ibuprofen may have a role in abrogating the catabolic processes which contribute to weight loss in patients with pancreatic cancer.
机译：这项研究的目的是研究环加氧酶抑制剂布洛芬对减肥的胰腺癌患者急性期蛋白反应和静息能量消耗（REE）的影响。不可切除的胰腺癌（n = 16）患者接受布洛芬（1200 mg，第1天，共7天（n = 10）或安慰剂（n = 6））治疗，另外还有17名与年龄相关的非癌症受试者研究人员在治疗前后立即进行了间接量热法，人体测量法，多频生物电阻抗分析和血清C反应蛋白（CRP）估算，与健康对照组相比，胰腺癌患者的总REE显着升高（1499 + / -71 vs 1377 +/- 58 kcal）（P <0.02）与治疗前的值（1468 +/- 99 kcal）相比，布洛芬组的平均REE显着下降（1386 +/- 89 kcal）（P <0.02） 0.02），而安慰剂组未见变化;布洛芬治疗组的血清CRP浓度也降低（布洛芬前为51 mg l-1;布洛芬后为29 mg l-1; P <0.05）这些结果表明，布洛芬可能在消除分解代谢过程中起作用导致胰腺癌患者体重减轻。

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