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首页> 外文期刊>British Journal of Cancer >Immunohistochemical expression of tenascin in normal stomach tissue, gastric carcinomas and gastric carcinoma in lymph nodes
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Immunohistochemical expression of tenascin in normal stomach tissue, gastric carcinomas and gastric carcinoma in lymph nodes

机译：肌腱蛋白在正常胃组织，胃癌和淋巴结中的胃癌的免疫组织化学表达

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The immunohistochemical expression of tenascin was examined in the normal adult mucosa of the stomach, primary tumours and lymph node metastases of gastric cancer patients. In normal gastric tissue tenascin was expressed in the muscularis mucosae, muscularis propria and vessel walls, however it was not expressed in either the mucosal connective tissue or the stromal tissue in the submucosal layer. In gastric cancer, tenascin was expressed in 35 of 85 primary tumours, and in 8 of 25 metastases in lymph nodes. Tenascin was located in the fibrous stroma surrounding foci of cancer. The expression of tenascin in the primary tumour did not correlate with the depth of invasion, lymph node metastasis or prognosis. Tenascin appears during the process of either malignant transformation or tumour progression in gastric cancer, and the positive expression of tenascin may be useful as a stromal marker for the early detection of gastric cancer.
机译：检测了肌腱蛋白在胃正常成人胃黏膜，胃癌患者原发肿瘤和淋巴结转移中的表达。在正常的胃组织中，肌腱蛋白在粘膜肌层，固有肌层和血管壁中表达，但在粘膜下层的粘膜结缔组织或基质组织中均未表达。在胃癌中，腱生蛋白表达于85个原发肿瘤中的35个，以及淋巴结转移25个中的8个。腱生蛋白位于癌灶周围的纤维基质中。肌腱蛋白在原发性肿瘤中的表达与浸润深度，淋巴结转移或预后无关。腱生蛋白在胃癌的恶性转化或肿瘤进展过程中出现，并且腱生蛋白的阳性表达可能用作早期检测胃癌的基质标志物。

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