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首页> 外文期刊>British Journal of Cancer >Subjective health estimations (SHE) in patients with advanced breast cancer: an adapted utility concept for clinical trials
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Subjective health estimations (SHE) in patients with advanced breast cancer: an adapted utility concept for clinical trials

机译：晚期乳腺癌患者的主观健康评估（SHE）：适用于临床试验的实用工具概念

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We wished to develop and validate a simple linear analogue self-assessment (LASA) scale to assess utility values in multicentre, multicultural breast cancer trials. We compared two variants of a LASA scale (score range 0-100) with different anchoring points [perfect health to worst possible health (subjective health estimation, SHE) and perfect health to death (SHED)] in 84 patients with advanced breast cancer. Feasibility was explored in the first 48 patients interviewed. Values from the LASA scales were compared with each other and with a time trade off (TTO) interview. Scores from the two LASA scales were highly correlated (r=0.8, P 56 years) had a lower mean on the SHE scale (53 vs 61; ANOVA P=0.04). We found that the two versions of the LASA scale were equivalent for clinical purposes. SHE appeared to provide a feasible, patient-preferred and valid alternative to lengthy TTO interviews in assessing the value patients attach to their present state of health in large-scale cancer clinical trials.
机译：我们希望开发并验证一个简单的线性模拟自我评估（LASA）量表，以评估多中心，多文化乳腺癌试验中的效用值。我们比较了84位晚期乳腺癌患者中LASA量表的两个变体（得分范围0-100）和不同的锚定点（完美健康至最差健康（主观健康估计，SHE）和完美健康至死（SHED））。在采访的前48位患者中探讨了可行性。将LASA量表的值相互比较，并进行时间权衡（TTO）访谈。两种LASA量表的得分高度相关（r = 0.8，P 56岁），SHE量表的平均值较低（53 vs 61; ANOVA P = 0.04）。我们发现LASA量表的两个版本在临床上是等效的。在评估大型癌症临床试验中患者对他们目前健康状况的重视程度时，SHE似乎为长期的TTO访谈提供了一种可行的，患者偏爱的有效选择。

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