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首页> 外文期刊>British Journal of Cancer >Transformation of human cells by SV40 virus
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Transformation of human cells by SV40 virus

机译：SV40病毒转化人细胞

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Fibroblast cultures were prepared from skin biopsies from 29 patients and tested for their susceptibility to transformation by simian virus SV40. Cells with a normal chromosome complement showed a mean transformation frequency of 25/106 cells but for cells from a single patient with Fanconi's anaemia, the value was 152/106 cells. An increased susceptibility to transformation was observed for cells from 6 patients with Down's syndrome 3 patients with trisomy 18, a patient with trisomy 18 for 5% of cells and a patient with trisomy 13. No increased susceptibility to transformation was found for cells with a chromosome complement of XO, XXY, XX/XX + 8, XX + partial 15q or XX + 9p. The susceptiability to transformation was related to susceptibility to SV40 virus infection, as measured by the number of infected cells which contained SV40 virus induced T antigen. This latter test was technically easier to perform and could serve to detect persons of increased susceptiability to transformation, since this may indicate an increased risk of natural malignant disease.
机译：从29位患者的皮肤活检样品中制备成纤维细胞培养物，并测试其对猿猴病毒SV40转化的敏感性。具有正常染色体补体的细胞显示平均转化频率为25/106个细胞，但对于患有Fanconi贫血的单个患者的细胞，该值为152/106个细胞。对于6名唐氏综合症患者，3名三体性患者，18号三体性患者，5％的细胞和13号三体性患者，观察到其对转化的敏感性增加。对于具有染色体的细胞，未发现对转化的敏感性增加XO，XXY，XX / XX + 8，XX +部分15q或XX + 9p的补码。如通过包含SV40病毒诱导的T抗原的被感染细胞的数量所测量，转化的敏感性与对SV40病毒感染的敏感性相关。后一种测试在技术上更容易执行，并且可以用来检测对转化的敏感性增加的人，因为这可能表明自然恶性疾病的风险增加。

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