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首页> 外文期刊>British Journal of Cancer >Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas
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Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas

机译：BCL-2蛋白在正常和发育异常的支气管上皮中以及在肺癌中的表达

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摘要

Although expression of the bcl-2 protein has been investigated in a number of non-haematological malignancies, little is known of its distribution in premalignant lesions. Expression of bcl-2 was investigated immunohistochemically in archival biopsies of normal (n = 8) and dysplastic bronchial epithelium (n = 56) and in 31 bronchial resection margins and their corresponding carcinomas. All dysplasias had lost the prominent basal staining pattern seen in histologically normal epithelium. Two were negative and six had occasional basal positive cells. In 37 cases up to 66% of the epithelial cells throughout the full epithelial thickness were bcl-2 positive with weak to moderate staining intensity. In 11 cases, all severe dysplasias, strong expression was observed in > 90% of the epithelial cells. Four patterns of bcl-2 expression in dysplasias were identified and an increasingly aberrant pattern of bcl-2 expression correlated with an increasing grade of dysplasia (Spearman's rank correlation, P 50% of the tumour cells were bcl-2 positive showed a survival advantage compared with those with 0-25% bcl-2-positive cells (P = 0.02). No correlation was found between p53 expression (Walker et al., 1994) and bcl-2 expression in dysplasias or carcinomas.
机译：尽管已经在许多非血液系统恶性肿瘤中研究了bcl-2蛋白的表达，但对其在恶性前病变中的分布了解甚少。在正常（n = 8）和增生异常的支气管上皮（n = 56）的存档活检组织中，以及在31个支气管切除切缘及其相应的癌中，免疫组织化学研究了bcl-2的表达。所有的异型增生都失去了在组织学上正常的上皮中所见的突出的基础染色模式。 2例阴性，6例偶有基础阳性细胞。在37例中，整个上皮厚度中多达66％的上皮细胞为bcl-2阳性，染色强度弱至中等。在所有严重异型增生的11例中，在> 90％的上皮细胞中观察到了强表达。鉴定了发育异常中的四种bcl-2表达模式，并且异常的bcl-2表达模式与发育异常程度增加相关（Spearman等级相关，P 50 ％的肿瘤细胞bcl-2阳性显示了生存优势与具有0-25％bcl-2阳性细胞的那些相比（P ＝ 0.02），在发育不良或癌中p53表达（Walker等，1994）与bcl-2表达之间没有相关性。

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