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首页> 外文期刊>British Journal of Cancer >Expression of transforming growth factor alpha, epidermal growth factor receptor and epidermal growth factor in precursor lesions to gastric carcinoma
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Expression of transforming growth factor alpha, epidermal growth factor receptor and epidermal growth factor in precursor lesions to gastric carcinoma

机译：转化生长因子α，表皮生长因子受体和表皮生长因子在胃癌前病变中的表达

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Epidermal growth factor (EGF), its related peptide transforming growth factor (TGF-alpha) and their common receptor (EGFR) have been implicated in the control of cell proliferation and differentiation in the gastrointestinal epithelium and may play an important role in gastric carcinogenesis. We compared the immunohistochemical expression and topographic distribution of these peptides using Western blot analysis in gastric carcinoma precursor lesions and in non-cancer tissue. We observed: (i) increased and extended expression of TGF-alpha in normal mucosa and hyperplasia in carcinoma fields compared with non-cancer controls; (ii) increased expression of EGFR in intestinal metaplasia (IM) from carcinoma fields compared with controls; (iii) EGF expression was not detected in normal mucosa and only weakly in IM; (iv) coexpression of TGF-alpha/EGFR and EGF/EGFR was higher in intestinal metaplasia in carcinoma fields than in non-cancer controls. We conclude that altered expression of TGF-alpha/EGFR is associated with morphological changes during gastric carcinogenesis. In this regard increased expression of TGF-alpha is a very early event which is subsequently followed by up-regulation of EGFR and this has important biological and clinical implications.
机译：表皮生长因子（EGF），其相关的肽转化生长因子（TGF-alpha）和它们的共同受体（EGFR）与胃肠道上皮细胞增殖和分化的控制有关，并且可能在胃癌的发生中起重要作用。我们使用蛋白质印迹分析比较了胃癌前体病变和非癌组织中这些肽的免疫组织化学表达和拓扑分布。我们观察到：（i）与非癌对照组相比，癌灶中正常黏膜和增生组织中TGF-α的表达增加和扩展; （ii）与对照组相比，EGFR在癌性肠上皮化生（IM）中的表达增加; （iii）在正常粘膜中未检测到EGF表达，而在IM中仅检测到EGF表达较弱; （iv）在癌灶肠上皮化生中，TGF-α/ EGFR和EGF / EGFR的共表达高于非癌对照组。我们得出结论，TGF-α/ EGFR的表达改变与胃癌发生过程中的形态变化有关。在这方面，TGF-α的表达增加是非常早期的事件，随后是EGFR的上调，这具有重要的生物学和临床意义。

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