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首页> 外文期刊>British Journal of Cancer >Differentiation Between the Embryonic and Tumour Specific Antigens on Chemically Induced Rat Tumours
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Differentiation Between the Embryonic and Tumour Specific Antigens on Chemically Induced Rat Tumours

机译：化学诱导的大鼠肿瘤上的胚胎抗原和肿瘤特异性抗原之间的区分

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摘要

The tumour specific antigens and tumour associated embryonic antigens expressed on chemically induced rat hepatomata and sarcomata have been shown to be different by means of blocking antibody studies. Serum from multiparous female rats contained blocking antibody which protected both tumour and embryo cells from the in vitro cytotoxic effect of lymph node cells from multiparous donors. These sera did not, however, block the cytotoxicity of lymph node cells from tumour immune rats for cells of the immunizing tumour. In addition, the tumour specific rejection antigens and embryonic antigens have been shown to have dissimilar locations in tumour cells.
机译：通过阻断抗体研究，已证明在化学诱导的大鼠肝肿大和肉瘤上表达的肿瘤特异性抗原和与肿瘤相关的胚胎抗原是不同的。来自多胎雌性大鼠的血清含有阻断抗体，该抗体保护肿瘤和胚胎细胞免受来自多胎供体的淋巴结细胞的体外细胞毒性作用。然而，这些血清并未阻止来自肿瘤免疫大鼠的淋巴结细胞对免疫肿瘤细胞的细胞毒性。另外，已经显示肿瘤特异性排斥抗原和胚胎抗原在肿瘤细胞中具有不同的位置。

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