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首页> 外文期刊>British Journal of Cancer >Assay of anti-cancer drugs in tissue culture: Relationship of relapse free interval (RFI) and in vitro chemosensitivity in patients with malignant cerebral glioma
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Assay of anti-cancer drugs in tissue culture: Relationship of relapse free interval (RFI) and in vitro chemosensitivity in patients with malignant cerebral glioma

机译：组织培养中抗癌药物的测定：恶性脑胶质瘤患者无复发间隔（RFI）与体外化学敏感性的关系

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One hundred and seventeen patients with cerebral glioma (Kernohan grades III and IV) were treated with adjuvant chemotherapy using procarbazine (PCB), CCNU and vincristine (VCR) following whole head irradiation. Cell cultures were prepared from 40 patients in this series and their sensitivity to each cytotoxic drug was assessed in a mictotitration assay with 35 S-methionine incorporation as the end point. Twenty-two of forty (55%) patients responded to PCB and/or CCNU in vitro, and sensitivity to these drugs was linked with increased RFI, whilst sensitivity to VCR was not. The RFI of patients who had responded to PCB or CCNU in vitro was significantly longer than the RFI of patients whose tumours failed to respond in vitro or patients who had not been tested. There was no difference in sex ratio, extent of operation, radiation dose and degree of steroid cover between responders, non-responders and untested groups. Grade III tumours tended to be more sensitive in vitro than grade IV tumours. The age of patients also influenced in vitro chemosensitivity. Patients with chemosensitive tumours in vitro tended to be younger than patients with insensitive tumours in vitro. Further statistical analysis, taking into account these prognostic factors, indicated an association between chemosensitivity in vitro and RFI.
机译：在全头照射后，用丙卡巴肼（PCB），CCNU和长春新碱（VCR）辅助化疗治疗了117例脑胶质瘤患者（Kernohan III级和IV级）。从该系列的40名患者中制备了细胞培养物，并在掺入35 S-蛋氨酸的微滴定分析中评估了它们对每种细胞毒性药物的敏感性。四十二名患者中有二十二名（55％）在体外对PCB和/或CCNU有反应，并且对这些药物的敏感性与RFI升高有关，而对VCR的敏感性则没有。体外对PCB或CCNU有反应的患者的RFI明显长于肿瘤对体外无反应的患者或未经测试的患者的RFI。应答者，未应答者和未经测试的人群之间的性别比例，手术程度，放射剂量和类固醇覆盖程度没有差异。 III级肿瘤在体外倾向于比IV级肿瘤更敏感。患者的年龄也影响了体外化学敏感性。体外具有化学敏感性肿瘤的患者往往比具有体外敏感性的患者年轻。考虑到这些预后因素，进一步的统计分析表明体外化学敏感性和RFI之间存在关联。

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