The effect of etoposide on human CFU-GM

R Bailey-Wood; C M Dallimore; T J Littlewood; D P Bentley

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The effect of etoposide on human CFU-GM

机译：依托泊苷对人CFU-GM的影响

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Etoposide is being used increasingly in the treatment of a variety of malignant conditions and in conjunction with autologous bone marrow transplantation. We have examined the effect of the drug on human CFU-GM as an indication of the response of these bone marrow progenitor cells to measured plasma concentrations. When etoposide is present in the routine assay for 7 days, 50% growth of colony-forming CFU-GM occurs at a concentration of 0.0098 micrograms ml-1. When bovine serum albumin or human serum albumin is present this value is increased to 0.042 and 0.375 micrograms ml-1. Protein binding therefore plays an important part in modifying in vitro response and possibly in vivo response of these progenitor cells to etoposide.

机译：依托泊苷被越来越多地用于治疗各种恶性疾病，并与自体骨髓移植一起使用。我们已经检查了该药物对人CFU-GM的作用，以表明这些骨髓祖细胞对血浆浓度的反应。当依托泊苷在常规测定中存在7天时，浓度为0.0098微克ml-1的菌落形成CFU-GM生长50％。当存在牛血清白蛋白或人血清白蛋白时，该值增加至0.042和0.375微克ml-1。因此，蛋白结合在改变这些祖细胞对依托泊苷的体外应答以及可能在体内应答中起重要作用。

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《British Journal of Cancer》 |1985年第4期|共5页
作者
R Bailey-Wood; C M Dallimore; T J Littlewood; D P Bentley;
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中图分类肿瘤学;
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The effect of etoposide on human CFU-GM

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