The role of catalytic iron in asbestos induced lipid peroxidation and DNA-strand breakage in C3H10T1/2 cells

CJ Turver; RC Brown

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The role of catalytic iron in asbestos induced lipid peroxidation and DNA-strand breakage in C3H10T1/2 cells

机译：催化铁在石棉诱导的C3H10T1 / 2细胞脂质过氧化和DNA链断裂中的作用

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The involvement of catalytic iron in the vitro activities of crocidolite asbestos has been investigated. Exposure of C3H10T1/2 cells to either the UICC crocidolite standard reference sample or a non fibrous (milled) derivative resulted in an increase of thiobarbituric acid reactive substances. This catalytic activity was inhibited by pretreatment with the iron chelator desferrioxamine. The effect of this activity on cellular DNA was measured in an assay based on the production of DNA-strand breaks. Increased levels of DNA-strand breaks were detected in cultures treated with both the milled and UICC crocidolite. Inclusion of desferrioxamine with the asbestos inhibited DNA-strand breakage. It is concluded the catalytic iron present on the dust is capable of damaging both lipid and DNA and that this could be an important mechanism in asbestos pathogenicity.

机译：已经研究了催化铁参与青石棉石棉的体外活性。将C3H10T1 / 2细胞暴露于UICC青石棉标准参考样品或非纤维（磨碎）衍生物中会导致硫代巴比妥酸反应性物质增加。通过用铁螯合剂去铁胺预处理可以抑制这种催化活性。在基于DNA链断裂的产生的测定中测量了该活性对细胞DNA的影响。在经碾磨和UICC青石棉处理的培养物中，检测到DNA链断裂水平增加。石棉中含有去铁胺可抑制DNA链断裂。可以得出结论，尘埃上存在的催化铁能够破坏脂质和DNA，这可能是石棉致病性的重要机制。

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《British Journal of Cancer》 |1987年第2期|共4页
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CJ Turver; RC Brown;
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6. The role of catalytic iron in asbestos induced lipid peroxidation and DNA-strand breakage in C3H10T1/2 cells. [O] . C. J. Turver, R. C. Brown 1987

机译：催化铁在石棉中诱导C3H10T1 / 2细胞脂质过氧化和DNA链断裂的作用。
7. The role of catalytic iron in asbestos induced lipid peroxidation and DNA-strand breakage in C3H10T1/2 cells. [O] . Turver, C. J., Brown, R. C. 1987

机译：催化铁在石棉中诱导C3H10T1 / 2细胞脂质过氧化和DNA链断裂的作用。

The role of catalytic iron in asbestos induced lipid peroxidation and DNA-strand breakage in C3H10T1/2 cells

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