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首页> 外文期刊>British Journal of Cancer >Pathological and biological features of mammographically detected invasive breast carcinomas
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Pathological and biological features of mammographically detected invasive breast carcinomas

机译：乳腺X射线摄影检测的浸润性乳腺癌的病理和生物学特征

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The pathological and biological features of a consecutive series of impalpable invasive breast carcinoma, detected by mammography in the prevalent round of the breast screening programme, have been compared with a clinically presenting group of carcinomas in age-matched patients. There was a significantly higher prevalence of tubular carcinomas as well-differentiated infiltrating ductal carcinomas in the mammographically detected group, and a lower prevalence of poorly differentiated infiltrating ductal carcinomas. Lymph node metastasis was found in 6.5% of the impalpable group compared with 53% of the clinical group. The prevalence of oestrogen receptor was much higher in the impalpable group (96%) than in the control group (67%), although there were no significant differences for progesterone receptor. The prevalence of pS2 was also much higher in the impalpable group, as was cathepsin D. This finding is surprising in view of the reported relationship between cathepsin D and poorer survival. p53 and c-erb-2 proteins were detectable in fewer impalpable carcinomas. The mean MIBI (Ki-67) index was lower in the impalpable group (11.6) than in the clinical group (15.25). Within the mammographically detected group there was a significant difference in the MIBI index between tubular carcinomas and the different grades of infiltrating ductal carcinomas, with a wide range in each category but no association with size. The impalpable carcinomas detected by mammography differ from clinically presenting carcinomas in many ways, raising the question of whether a proportion or all would progress (dedifferentiate) with time.
机译：在乳房筛查计划的普遍阶段中，通过乳房X线照相术检测到的一系列连续性无法浸润性乳腺癌的病理和生物学特征已与年龄相匹配的患者中临床上出现的一组癌进行了比较。在乳腺钼靶检查组中，高分化的浸润性导管癌的肾小管癌的患病率明显较高，而低分化的浸润性导管癌的患病率较低。在6.5％的不可触及组中发现淋巴结转移，而在临床组中则为53％。尽管孕激素受体没有显着差异，但不可触及组的雌激素受体患病率（96％）比对照组（67％）高得多。与组织蛋白酶D相比，在不可触及组中pS2的患病率也高得多。鉴于已报道的组织蛋白酶D与较差的生存率之间的关系，这一发现令人惊讶。 p53和c-erb-2蛋白可在较少的难治性癌症中检出。不可植入组（11.6）的平均MIBI（Ki-67）指数低于临床组（15.25）。在乳腺X射线摄影检测组中，小管癌和不同级别的浸润性导管癌之间的MIBI指数存在显着差异，各类别的差异很大，但与大小无关。通过乳房X线照相术检测到的无法触及的癌症在许多方面与临床表现的癌症不同，这引发了一个问题，即一部分还是全部会随着时间发展（去分化）。

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