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首页> 外文期刊>British Journal of Cancer >Prognostic value of epidermal growth factor-receptor, T138 and T43 expression in bladder cancer
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Prognostic value of epidermal growth factor-receptor, T138 and T43 expression in bladder cancer

机译：表皮生长因子受体，T138和T43表达在膀胱癌中的预后价值

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Tumour-associated markers defined by monoclonal antibodies have proven useful to phenotype bladder tumours. In order to evaluate the prognostic value of such markers, we performed an immunohistochemical study on 57 transitional cell carcinomas (23 infiltrative and 34 superficial tumours) and ten healthy bladders using monoclonal antibodies against the external domain of the epidermal growth factor receptor (EGFR) and against the tumour-associated antigens T43, 19A211 and T138. Immunohistochemistry was performed on frozen sections using a two-step alkaline phosphatase method. The staining pattern obtained with each antibody was analysed according to the TNM classification, and results were analysed according to the subsequent clinical course. 19A211 preferentially stained superficial tumours, and T43, T138 and EGFR preferentially stained invasive tumours. Three monoclonal antibodies appeared to have prognostic value, since progression rate survival was significantly (log-rank test) associated with their expression of EGFR (P = 0.017), T138 (P = 0.0009) and T43 (P = 0.031). T138 expression was found to have an independent significant prognostic value using a stepwise logistic regression. T138 antibody may add significant information to classical pathological parameters.
机译：由单克隆抗体定义的与肿瘤相关的标志物已被证明可用于表型膀胱肿瘤。为了评估此类标记物的预后价值，我们使用了针对表皮生长因子受体（EGFR）和EGFR外域的单克隆抗体，对57例移行性细胞癌（23例浸润性和34例浅表性肿瘤）和10个健康膀胱进行了免疫组织化学研究。抗与肿瘤相关的抗原T43、19A211和T138。使用两步碱性磷酸酶方法对冷冻切片进行免疫组织化学。根据TNM分类分析每种抗体获得的染色模式，并根据随后的临床过程分析结果。 19A211优先染色浅表肿瘤，而T43，T138和EGFR优先染色浸润性肿瘤。三种单克隆抗体似乎具有预后价值，因为其EGFR（P = 0.017），T138（P = 0.0009）和T43（P = 0.031）的表达与生存率显着相关（对数秩检验）。使用逐步逻辑回归分析发现T138表达具有独立的重要预后价值。 T138抗体可能会为经典病理参数添加重要信息。

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