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首页> 外文期刊>British Journal of Cancer >Height, body mass index, and prostate cancer: a follow-up of 950|[thinsp]|000 Norwegian men
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Height, body mass index, and prostate cancer: a follow-up of 950|[thinsp]|000 Norwegian men

机译：身高，体重指数和前列腺癌：950 | [thinsp] | 000挪威男性的随访

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摘要

The present study explored body mass index (BMI), height, and risk of prostate cancer in a large Norwegian cohort of 950?000 men aged 20–74 years, whose height and weight were measured in a standardised way in the period 1963–1999. These were followed for an average of 21 years. The Cox proportional hazard models were used in the analyses. During follow-up, 33?300 histologically verified cases of prostate cancer were registered. The risk of prostate cancer increased by both BMI and height. The magnitude of the increase by BMI was modest, the relative risk (RR) of obese men (BMI30) compared with normal weighted was 1.09 (95% CI: 1.04–1.15). However, the RR at age 50–59 years was 1.58 (95% CI: 1.29–1.94) in men being obese at about age 45 years compared with normal weighted men. The tallest men had an RR of 1.72 (95% CI: 1.46–2.04) compared with the shortest men. The overall effect of BMI on the incidence of prostate cancer was modest. The larger effect found in men aged 50–59 years might partly explain the previous inconsistent findings.
机译：本研究探讨了950-000名年龄在20-74岁之间的挪威大型队列的体重指数（BMI），身高和患前列腺癌的风险，该人群的身高和体重是在1963-1999年间以标准化方式测量的。这些平均随访了21年。分析中使用了Cox比例风险模型。在随访期间，登记了33？300例经组织学证实的前列腺癌病例。 BMI和身高都会增加前列腺癌的风险。 BMI增加的幅度是适度的，与正常体重相比，肥胖男性（BMI30）的相对风险（RR）为1.09（95％CI：1.04-1.15）。但是，与体重正常的男性相比，肥胖的男性在45岁左右时，其50-59岁时的RR为1.58（95％CI：1.29-1.94）。与矮个子的男人相比，个子最高的男人的RR为1.72（95％CI：1.46-2.04）。 BMI对前列腺癌发生率的总体影响是中等的。在50-59岁的男性中发现更大的影响，可能部分解释了以前不一致的发现。

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