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首页> 外文期刊>British Journal of Cancer >Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma
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Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma

机译：Caveolin-1表达的恢复抑制头颈部鳞状细胞癌的生长和转移

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摘要

Caveolin-1 (Cav-1) plays an important role in modulating cellular signalling, but its role in metastasis is not well defined. A significant reduction in Cav-1 levels was detected in lymph node metastases as compared with primary tumour of head and neck squamous cell carcinoma (HNSCC) specimens (Pcav-1 cDNA (CavS) with cells expressing an empty vector (EV) in vitro and in the orthotopic xenograft model. Overexpression of Cav-1 suppressed growth of the CavS tumours compared with the EV tumours. The incidence of lung metastases was significantly lower in animals carrying CavS tumours than those with EV tumours (P=0.03). In vitro, CavS cells displayed reduced cell growth, invasion, and increased anoikis compared with EV cells. In CavS cells, Cav-1 formed complex with integrin β1 and Src. Further application of integrin β1 neutralising antibody or Src inhibitor PP2 to EV cells illustrated similar phenotypes as CavS cells, suggesting that Cav-1 may play an inhibitory role in tumorigenesis and lung metastasis through regulating integrin β1- and Src-mediated cell–cell and cell–matrix interactions.
机译：Caveolin-1（Cav-1）在调节细胞信号传导中起重要作用，但其在转移中的作用尚未明确。与头颈部鳞状细胞癌（HNSCC）标本（Pcav-1 cDNA（CavS）的原发肿瘤在体外和体外表达空载体（EV）的细胞相比，淋巴结转移中Cav-1水平显着降低。在原位异种移植模型中，与EV肿瘤相比，Cav-1的过表达抑制了CavS肿瘤的生长;携带CavS肿瘤的动物的肺转移发生率明显低于EV肿瘤（P = 0.03）。与EV细胞相比，CavS细胞显示出减少的细胞生长，侵袭和增加的缺氧;在CavS细胞中，Cav-1与整联蛋白β1和Src形成复合物;将整联蛋白β1中和抗体或Src抑制剂PP2进一步应用于EV细胞，其表型与CavS细胞，提示Cav-1可能通过调节整联蛋白β1和Src介导的细胞与细胞和细胞与基质的相互作用而在肿瘤发生和肺转移中发挥抑制作用。

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