...
首页> 外文期刊>British Journal of Cancer >Analysis of survival following treatment of tumour-induced hypercalcaemia with intravenous pamidronate (APD)
【24h】

Analysis of survival following treatment of tumour-induced hypercalcaemia with intravenous pamidronate (APD)

机译:静脉注射帕米膦酸(APD)治疗肿瘤引起的高钙血症后的生存分析

获取原文
           

摘要

The outcome of 114 patients with tumour-induced hypercalcaemia (TIH) treated between January 1992 and June 1993 with intravenous pamidronate (APD) was retrospectively analysed. The median overall survival was 55 days (range 3 days to > 21 months): 86 days if systemic anti-cancer therapy was available and only 35 days if not (P < 0.001). Survival was also significantly better for those who became normocalcaemic post APD (53 days vs 19 days, P < 0.001). There was no survival difference with respect to patient sex, age, tumour type, treatment of bone metastases with radiotherapy, initial calcium level, initial dose of APD or time from tumour diagnosis to first TIH. In those patients in whom systemic anti-cancer therapy is available, treatment with APD improves survival, but in all other patients the primary aim of treatment should be symptom control. This study confirms the dismal prognosis of TIH.
机译:回顾性分析了1992年1月至1993年6月间用静脉输注帕米膦酸盐(APD)治疗的114例肿瘤诱发的高钙血症(TIH)患者的结局。中位总生存期为55天(从3天到> 21个月不等):如果可以进行全身抗癌治疗,则为86天;否则,只有35天(P <0.001)。 APD后变为正常血液钙化者的生存率也显着提高(53天vs 19天,P <0.001)。在患者性别,年龄,肿瘤类型,放射治疗骨转移的治疗,初始钙水平,APD初始剂量或从肿瘤诊断到首次TIH的时间方面,生存率无差异。在那些可以进行全身抗癌治疗的患者中,APD治疗可以提高生存率,但是在所有其他患者中,治疗的主要目的应该是控制症状。这项研究证实了TIH的预后不良。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号