Pharmacokinetics of doxorubicin co-administered with high-dose verapamil

M Gigante; G Toffoli; M Boiocchi

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Pharmacokinetics of doxorubicin co-administered with high-dose verapamil

机译：阿霉素与大剂量维拉帕米合用的药代动力学

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The potential for the modification of the pharmacokinetics of doxorubicin (DOX) concurrently administered with high-dose verapamil (VER) has been investigated in 17 patients with advanced neoplasms refractory to drugs belonging to the multidrug resistance spectrum. Steady-state concentration of DOX, systemic clearance and urinary excretion were analysed. No significant difference was found between the kinetic parameters estimated for DOX at different levels of VER and those reported for doxorubicin as single agent. It can be concluded that VER does not appear to modify DOX kinetics.

机译：在17例对多药耐药谱属于难治性药物的晚期肿瘤患者中，已经研究了与高剂量维拉帕米（VER）同时使用的阿霉素（DOX）药代动力学修饰的潜力。分析DOX的稳态浓度，全身清除率和尿排泄量。在不同水平的VER上针对DOX估算的动力学参数与作为单一药物的阿霉素报道的动力学参数之间没有发现显着差异。可以得出结论，VER似乎没有改变DOX动力学。

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《British Journal of Cancer》 |1995年第1期|共3页
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M Gigante; G Toffoli; M Boiocchi;
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中图分类肿瘤学;
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1. Direct interaction between verapamil and doxorubicin causes the lack of reversal effect of verapamil on P-glycoprotein mediated resistance to doxorubicin in vitro using L1210/VCR cells. [J] . Breier A, Drobna Z, Barancik M Neoplasma: Journal of Experimental and Clinical Oncology . 1998,第4期

机译：使用L1210 / VCR细胞体外，维拉帕米与阿霉素之间的直接相互作用导致维拉帕米对P-糖蛋白介导的对阿霉素的抗性缺乏逆转作用。
2. Pharmacokinetics of intravenously administered stealth liposomal doxorubicin modulated with verapamil in rats. [J] . Wang JC, Liu XY, Lu WL, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2006,第1期

机译：用维拉帕米调节的静脉内注射隐性脂质体阿霉素的药代动力学在大鼠中。
3. Toxicologic and pharmacokinetic study of low doses of verapamil combined with doxorubicin. [J] . Candussio L, Decorti G, Crivellato E, Life sciences . 2002,第26期

机译：低剂量维拉帕米联合阿霉素的毒理学和药代动力学研究。
4. A pharmacokinetic drug-drug interaction model of simvastatin and verapamil in humans [C] . Methaneethorn Janthima, Chamnansua Munlikar, Kaewdang Natnaree, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：辛伐他汀与维拉帕米在人体内的药代动力学药物相互作用模型
5. The effect of inflammation and anti-TNFalpha on pharmacokinetics and pharmacodynamics of verapamil: A disease-drug interaction. [D] . Ling, Spencer Yu-Hong. 2008

机译：炎症和抗TNFα对维拉帕米药代动力学和药效学的影响：一种疾病-药物相互作用。
6. Pharmacokinetics of doxorubicin co-administered with high-dose verapamil. [O] . M. Gigante, G. Toffoli, M. Boiocchi 1995

机译：阿霉素与大剂量维拉帕米合用的药代动力学。
7. Pharmacokinetics of doxorubicin co-administered with high-dose verapamil. [O] . Gigante, M., Toffoli, G., Boiocchi, M. 1995

机译：阿霉素与大剂量维拉帕米合用的药代动力学。

Pharmacokinetics of doxorubicin co-administered with high-dose verapamil

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