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首页> 外文期刊>British Journal of Cancer >Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters
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Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters

机译：神经内分泌肿瘤中间碘苄基胍的吸收是由水泡单胺转运蛋白介导的

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The radio-iodinated noradrenaline analogue meta-iodobenzylguanidine (MIBG) can be used for scintigraphy and radiation therapy of neuroendocrine (NE). The aim of the present study was to study the importance of vesicular monoamine transporters (VMATs) for the uptake of 123I-MIBG in NE tumours. In nude mice, bearing the human transplantable midgut carcinoid GOT1, all organs and xenografted tumours accumulated 123I after i.v. injection of 123I-MIBG. A high concentration of 123I was maintained in GOT1 tumours and adrenals, which expressed VMATs, but rapidly decreased in all other tissues. In the VMAT-expressing NE tumour cell lines GOT1 and BON and in VMAT-expressing primary NE tumour cell cultures (carcinoids, n=4 and pheochromocytomas, n=4), reserpine significantly reduced the uptake of 123I-MIBG. The membrane pump inhibitor clomipramine had no effect on the uptake of 123I-MIBG in GOT1 and BON cells, but inhibited the uptake in one out of four primary carcinoid cell cultures and three out of four primary pheochromocytoma cell cultures. In conclusion, VMATs and secretory granules are of importance for the uptake and retention of 123I-MIBG in NE tumours. Information about the type and degree of expression of VMATs in NE tumours may be helpful in future to select patients suitable for radiation therapy with radio-iodinated MIBG.
机译：放射性碘去甲肾上腺素类似物间碘苄基胍（MIBG）可用于神经内分泌（NE）的闪烁显像和放射治疗。本研究的目的是研究水泡单胺转运蛋白（VMATs）在NE肿瘤中摄取123I-MIBG的重要性。在裸鼠中，携带人可移植中肠类癌GOT1的小鼠在静脉输注后所有器官和异种移植肿瘤均累积123I。注射123I-MIBG。在表达VMAT的GOT1肿瘤和肾上腺中维持高浓度的123I，但在所有其他组织中迅速下降。在表达VMAT的NE肿瘤细胞系GOT1和BON以及表达VMAT的原发性NE肿瘤细胞培养物中（类癌，n = 4和嗜铬细胞瘤，n = 4），利血平显着降低了123I-MIBG的摄取。膜泵抑制剂氯米帕明对GOT1和BON细胞中123I-MIBG的吸收没有影响，但抑制了四种原发性类癌细胞培养物中的一种和四种原发性嗜铬细胞瘤细胞培养物中的三种。总之，VMAT和分泌颗粒对于NE肿瘤中123I-MIBG的吸收和保留很重要。有关NE肿瘤中VMATs表达类型和程度的信息，将来可能有助于选择适合放射碘MIBG放射治疗的患者。

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