The MEK1|[sol]|2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

S V Holt; A Logié; R Odedra; A Heier; S P Heaton; D Alferez; B R Davies; R W Wilkinson; P D Smith

首页> 外文期刊>British Journal of Cancer >The MEK1|[sol]|2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

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The MEK1|[sol]|2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

机译：MEK1 | [sol] | 2抑制剂selumetinib（AZD6244; ARRY-142886）在人肿瘤异种移植模型中与常规化学治疗剂联合使用时可增强抗肿瘤功效

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Background:The Ras/RAF/MEK/ERK pathway is frequently deregulated in cancer and a number of inhibitors that target this pathway are currently in clinical development. It is likely that clinical testing of these agents will be in combination with standard therapies to harness the apoptotic potential of both the agents. To support this strategy, it has been widely observed that a number of chemotherapeutics stimulate the activation of several intracellular signalling cascades including Ras/RAF/MEK/ERK. The MEK1/2 inhibitor selumetinib has been shown to have anti-tumour activity and induce apoptotic cell death as a monotherapy.

机译：背景：Ras / RAF / MEK / ERK途径在癌症中经常被放松调节，目前许多针对该途径的抑制剂正在临床开发中。这些药物的临床测试可能会与标准疗法相结合，以利用两种药物的凋亡潜力。为了支持该策略，已经广泛观察到许多化学疗法刺激包括Ras / RAF / MEK / ERK在内的几种细胞内信号级联反应的激活。已经证明，MEK1 / 2抑制剂selumetinib具有抗肿瘤活性，并且可以通过单一疗法诱导凋亡性细胞死亡。

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《British Journal of Cancer》 |2012年第5期|共9页
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S V Holt; A Logié; R Odedra; A Heier; S P Heaton; D Alferez; B R Davies; R W Wilkinson; P D Smith;
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中图分类肿瘤学;
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1. The MEK1|[sol]|2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models [J] . S V Holt, A Logié, R Odedra, British Journal of Cancer . 2012,第5期

机译：MEK1 | [sol] | 2抑制剂selumetinib（AZD6244; ARRY-142886）在人肿瘤异种移植模型中与常规化学治疗剂联合使用时可增强抗肿瘤功效
2. Acute tumour response to the MEK1|[sol]|2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI [J] . M Beloueche-Babari, Y Jamin, V Arunan, British Journal of Cancer . 2013,第6期

机译：通过非侵入性扩散加权MRI评价对MEK1 | [sol] | 2抑制剂selumetinib（AZD6244，ARRY-142886）的急性肿瘤反应
3. The MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) appears as an efficient targeted therapy when used in an adjuvant setting in patient-derived xenografts of uveal melanoma [J] . Diallo B., Massonnet G., El-Botty R., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016,第Null期

机译：MEK1 / 2抑制剂selumetinib（AZD6244; ARRY-142886）当用于患者来源的葡萄膜黑色素瘤异种移植的佐剂时，似乎是一种有效的靶向疗法
4. Combination of angiogenesis inhibitors increases the anti-tumor efficacy of photodynamic therapy in a human bladder tumor xenograft model [C] . Ramaswamy Bhuvaneswari, Yik Yuen Gan, Patricia SP Thong, World congress of the International Photodynamic Association . 2009

机译：血管生成抑制剂的组合增加了光动力疗法在人膀胱肿瘤异种移植模型中的抗肿瘤功效
5. The MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models [O] . S V Holt, A Logié, R Odedra, 2012

机译：MEK1 / 2抑制剂selumetinib（AZD6244; ARRY-142886）在人肿瘤异种移植模型中与常规化学治疗剂联合使用时可增强抗肿瘤功效
6. The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models [O] . Holt, S V, Logié, A, Odedra, R, 2012

机译：mEK1 / 2抑制剂selumetinib（aZD6244; aRRY-142886）与人类肿瘤异种移植模型中的常规化疗药物联合使用可增强抗肿瘤功效

The MEK1|[sol]|2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

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