Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay

T Osako; H Tsuda; R Horii; T Iwase; H Yamauchi; H Yagata; K Tsugawa; K Suzuki; T Kinoshita; F Akiyama; S Nakamura

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Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay

机译：术前全身化疗治疗乳腺癌患者淋巴结转移的分子检测：使用一步法核酸扩增测定的前瞻性多中心试验

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Background:For patients with breast cancer treated with preoperative chemotherapy, residual tumour burden in lymph nodes is the strongest prognostic factor. However, conventional pathological examination has limitations that hinder the accurate and reproducible measurement. The one-step nucleic acid amplification (OSNA) assay is a novel molecular method for detecting nodal metastasis. In this prospective multicentre trial, we assessed the performance of the OSNA assay in detecting nodal metastasis after chemotherapy.

机译：背景：对于接受术前化学疗法治疗的乳腺癌患者，淋巴结中残留的肿瘤负荷是最强的预后因素。然而，常规的病理检查具有局限性，妨碍了准确和可重复的测量。一步式核酸扩增（OSNA）分析是检测淋巴结转移的新型分子方法。在这项前瞻性多中心试验中，我们评估了OSNA分析在检测化学疗法后淋巴结转移中的性能。

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《British Journal of Cancer》 |2013年第6期|共6页
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T Osako; H Tsuda; R Horii; T Iwase; H Yamauchi; H Yagata; K Tsugawa; K Suzuki; T Kinoshita; F Akiyama; S Nakamura;
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中图分类肿瘤学;
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1. One-Step Nucleic Acid Amplification Assay for Detection of Axillary Lymph Node Metastases in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy [J] . Takamoto Kaori, Shimazu Kenzo, Naoi Yasuto, Annals of surgical oncology . 2016,第1期

机译：一步核酸扩增检测新辅助化学疗法治疗乳腺癌患者腋窝淋巴结转移
2. Intra-operative sentinel lymph node metastasis detection in breast cancer by “One-step Nucleic Acid Amplification (OSNA)” – results of the French multicentre prospective study [J] . M.A.Le Frere Belda, C.Charon Barra, H.Crouet, European Journal of Cancer Supplements . 2008,第7期

机译：“一步法核酸扩增（OSNA）”检测乳腺癌的术中前哨淋巴结转移-法国多中心前瞻性研究结果
3. Intra-operative sentinel lymph node metastasis detection in breast cancer by “One-step Nucleic Acid Amplification (OSNA)” – results of the French multicentre prospective study [J] . M.A.Le Frere Belda, C.Charon Barra, H.Crouet, European Journal of Cancer Supplements . 2008,第7期

机译：“一步法核酸扩增（OSNA）”检测乳腺癌的术中前哨淋巴结转移-法国多中心前瞻性研究结果
4. A comparison of maximum entropy estimation and multivariate logistic regression in the prediction of axillary lymph node metastasis in early breast cancer patients [C] . Poh Lian Choong, de Silva, C.J.S. . 1996

机译：最大熵估计和多元逻辑回归在早期乳腺癌患者腋窝淋巴结转移预测中的比较
5. Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay [O] . T Osako, H Tsuda, R Horii, 2013

机译：术前全身化学疗法治疗的乳腺癌患者淋巴结转移的分子检测：使用一步法核酸扩增测定的前瞻性多中心试验
6. Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay [O] . T Osako, H Tsuda, R Horii, 2013

机译：术前全身化疗治疗乳腺癌患者淋巴结转移的分子检测：一种使用单步核酸扩增测定的前瞻性多期试验

Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay

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