Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells

C Martínez-Campa; A González; M D Mediavilla; C Alonso-González; V Alvarez-García; E J Sánchez-Barceló; S Cos

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Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells

机译：褪黑素通过调节乳腺癌细胞中环氧合酶的表达和活性来抑制芳香化酶启动子的表达

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Background:Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases and assess whether the effects of melatonin are related to its effects on intracellular cAMP, in MCF-7 cells.

机译：背景：褪黑素减少了干扰雌激素信号通路的乳腺癌的发展，并且还抑制了芳香化酶的活性和表达。我们的目标是研究褪黑素通过其修饰芳香酶表达的启动子，评估褪黑素调节环加氧酶的能力，并评估褪黑素的作用是否与其对细胞内cAMP的作用有关（在MCF-7细胞中）。

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《British Journal of Cancer》 |2009年第9期|共7页
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C Martínez-Campa; A González; M D Mediavilla; C Alonso-González; V Alvarez-García; E J Sánchez-Barceló; S Cos;
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1. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells [J] . C Martínez-Campa, A González, M D Mediavilla, British Journal of Cancer . 2009,第9期

机译：褪黑素通过调节乳腺癌细胞中环氧合酶的表达和活性来抑制芳香化酶启动子的表达
2. 4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells. [J] . Su B, Mershon SM, Stonerock LA, The Journal of Steroid Biochemistry and Molecular Biology . 2008,第1a2期

机译：4-羟基苯基视黄酰胺（4HPR）衍生物调节乳腺癌细胞中的芳香化酶活性和表达。
3. Shu-Gan-Liang-Xue Decoction Simultaneously Down-regulates Expressions of Aromatase and Steroid Sulfatase in Estrogen Receptor Positive Breast Cancer Cells [J] . Xue-song Fu, Ping-ping Li 中国癌症研究：英文版 . 2011,第003期

机译：舒肝凉血汤同时下调雌激素受体阳性乳腺癌细胞中芳香酶和甾族硫酸酯酶的表达
4. ERβ regulates miR-21 expression and inhibits invasion and metastasis in cancer cells [C] . Junmei Tian, Zhenzhen Tu, Yueqing Gu Biophotonics and immune responses VII. . 2012

机译：ERβ调节miR-21表达并抑制癌细胞的侵袭和转移
5. Characterization of the HP1α gene promoter and implications for reduced expression in breast cancer cells [D] . Lieberthal, Jason Glen 2008

机译：HP1α基因启动子的表征及其对乳腺癌细胞表达降低的影响
6. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells [O] . C Martínez-Campa, A González, M D Mediavilla, 2009

机译：褪黑素通过调节乳腺癌细胞中环氧合酶的表达和活性来抑制芳香化酶启动子的表达
7. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells [O] . Martínez-Campa, C, González, A, Mediavilla, M D, 2009

机译：褪黑素通过调节乳腺癌细胞中环氧合酶的表达和活性来抑制芳香化酶启动子的表达

Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells

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