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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Interference of fetal hemoglobin and labile glycosylated hemoglobin with measurements of glycosylated hemoglobin.
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Interference of fetal hemoglobin and labile glycosylated hemoglobin with measurements of glycosylated hemoglobin.

机译：胎儿血红蛋白和不稳定的糖基化血红蛋白干扰糖基化血红蛋白的测量。

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摘要

We examined the effect of fetal hemoglobin and labile glycosylated hemoglobin on a number of diverse methods used to measure glycosylated hemoglobin. Samples were supplemented with various amounts of cord blood to give proportions of fetal hemoglobin ranging from 1 to 20% of total hemoglobin concentration. Procedures in which the separation of hemoglobin A1 from the major hemoglobin A fraction is based on differences in ionic properties (cation-exchange chromatography and electrophoresis) are subject to interference by fetal hemoglobin, whereas procedures that base the quantitation on other properties (colorimetry and affinity column chromatography) are not. The same procedures that are affected by the presence of fetal hemoglobin are also subject to interference by labile glycosylated hemoglobin. We conclude that the affinity chromatographic and colorimetric methods may give a more nearly accurate determination of glycosylated hemoglobin.
机译：我们检查了胎儿血红蛋白和不稳定的糖基化血红蛋白对多种用于测量糖基化血红蛋白的方法的影响。给样品补充各种量的脐带血，以使胎儿血红蛋白的比例为总血红蛋白浓度的1％至20％。血红蛋白A1与主要血红蛋白A馏分基于离子性质的差异进行分离的程序（阳离子交换色谱和电泳）会受到胎儿血红蛋白的干扰，而将定量基于其他性质（比色法和亲和力）的程序柱色谱法）不是。受胎儿血红蛋白存在影响的相同程序也受到不稳定的糖基化血红蛋白的干扰。我们得出结论，亲和色谱法和比色法可能会给出糖基化血红蛋白的更接近准确的测定结果。

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