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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Ability of the 1(2)s rule to detect substandard performance in interlaboratory proficiency testing.
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Ability of the 1(2)s rule to detect substandard performance in interlaboratory proficiency testing.

机译：1（2）s规则检测实验室间能力验证中不合格性能的能力。

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摘要

The most common evaluation criterion used by regulatory and voluntary interlaboratory proficiency testing (PT) programs to judge the quality of chemistry results is based on the group mean +/- 2.0 standard deviations (SD), the 1(2)s rule. The mean and SD are those of the selected PT population. Through computer simulations we have quantified, for the first time, the ability of the 1(2)s criterion to detect "acceptable" as well as substandard ("unacceptable") intralaboratory performance by PT. We found that the 1(2)s rule correctly identifies "acceptable" performance--i.e., low intralaboratory coefficient of variation (CV) values and small bias values--greater than 90% of the time. However, this criterion fails to detect laboratories with "unacceptable" bias and (or) CV at least 23% of the time. The high failure rate of the 1(2)s rule raises serious questions about its appropriateness for use by PT programs.
机译：监管和自愿性实验室间熟练度测试（PT）程序用来判断化学结果质量的最常见评估标准是基于1（2）s准则的组平均值+/- 2.0标准差（SD）。平均值和SD是所选PT人群的平均值和SD。通过计算机模拟，我们首次量化了1（2）​​s标准检测PT的“可接受的”和不合格的（“不可接受的”）实验室内性能的能力。我们发现1（2）s规则正确地识别了“可接受的”性能，即实验室内部变异系数（CV）值低和偏差值小-大于90％的时间。但是，该标准无法至少在23％的时间内检测到具有“不可接受的”偏倚和（或）简历的实验室。 1（2）s规则的高失败率引发了有关其是否适合PT程序使用的严重问题。

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