• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Hydrocortisone succinate and hydrocortisone simultaneously determined in plasma by reversed-phase liquid chromatography, and their pharmacokinetics in asthmatic children.
【24h】

Hydrocortisone succinate and hydrocortisone simultaneously determined in plasma by reversed-phase liquid chromatography, and their pharmacokinetics in asthmatic children.

机译：反相液相色谱法同时测定了血浆中琥珀酸氢化可的松和氢化可的松的含量，及其在哮喘儿童中的药代动力学。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hydrocortisone succinate and hydrocortisone are chromatographed with a mobile phase consisting of sodium acetate/acetonitrile (77/23, by vol), the effluent being monitored at 254 nm. p-Hydroxybenzoate-N-propyl is used as the internal standard. Detection limits are 0.5 mg/L for hydrocortisone succinate, 0.2 mg/L for hydrocortisone. For five different concentrations the respective mean analytical recoveries were 88.2% and 100.5%, the mean intra-assay CVs for slope 3.9% and 2.1%, and the inter-assay CVs 3.3% and 1.6%. Simultaneous measurement of hydrocortisone and its succinate ester may be useful for pharmacokinetic study. Concentration-time profiles for plasma after administration of hydrocortisone sodium succinate are presented.
机译：琥珀酸氢化可的松和氢化可的松用由乙酸钠/乙腈（体积比为77/23）组成的流动相进行色谱分离，在254 nm处监测流出液。对羟基苯甲酸酯-N-丙基用作内标。琥珀酸氢化可的松的检出限为0.5 mg / L，氢化可的松的检出限为0.2 mg / L。对于五个不同的浓度，各自的平均分析回收率分别为88.2％和100.5％，斜率的平均测定内CV为3.9％和2.1％，测定间的CV为3.3％和1.6％。同时测量氢化可的松及其琥珀酸酯可能对药代动力学研究有用。显示了氢化可的松琥珀酸钠给药后血浆的浓度-时间曲线。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号