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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Lower Maternal PLAC1 mRNA in Pregnancies Complicated with Vaginal Bleeding (Threatened Abortion &20 Weeks) and a Surviving Fetus
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Lower Maternal PLAC1 mRNA in Pregnancies Complicated with Vaginal Bleeding (Threatened Abortion &20 Weeks) and a Surviving Fetus

机译：孕妇中较低的孕妇PLAC1 mRNA并发阴道流血（堕胎<20周）和胎儿存活

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Trophoblastic cells of the placenta enter the maternal circulation and can be isolated there along with their specific mRNAs (1)(2). Increased concentrations of mRNA for corticotropin-releasing hormone, which is synthesized in the placenta, are seen in the blood of patients affected by preeclampsia (3), and panels of mRNAs(4) can be used to test for a disease of interest. The mRNA concentration in blood may vary with intracellular expression and with the number of trophoblastic cells expressing that specific mRNA per unit of blood. We hypothesize that pregnancies affected by a threatened abortion, but with a viable embryo, exhibit lower concentrations of mRNA for the placenta-expressed gene PLAC1 because of possible underlying delayed or abnormal placental growth at the time of maternal blood collection.We studied 10 pregnant women admitted for a threatened abortion at 20 weeks of gestation (threatened abortion group). The study was approved by our local ethics committee, and all patients gave informed consent. All fetuses with abnormal karyotypes and pregnant women with preeclampsia, pre- or postterm delivery, uterine pathology such as myomas or malformations, placenta abruptio, loss to follow-up, and a vaginal or cervical lesion visualized on clinical examination that could explain the vaginal bleeding were excluded from the study. We also excluded those women who had vaginal bleeding and a subsequent miscarriage because villus destruction, apoptosis, and embryo death could increase the number of circulating placental cells and nucleic acids in the maternal blood, as could abnormal fetal karyotype, fetal malformation, and abnormal maternal immune response. Placental abruption observed later in the pregnancy was also excluded as a possible source of feto-maternal hemorrhage. During hospitalization, all women were maintained at complete bed rest, and routine ultrasound examinations and endocrine (β-hCG) evaluation were carried out. We also studied 66 normal pregnancies as controls. All …
机译：胎盘的滋养层细胞进入母体循环，可以与它们的特异性mRNA一起分离到母体循环中（1）（2）。在子痫前期患者的血液中可见到胎盘中合成的促肾上腺皮质激素释放激素的mRNA浓度增加（3），而mRNA面板（4）可用于检测目标疾病。血液中的mRNA浓度可能随细胞内表达以及每单位血液表达该特定mRNA的滋养细胞数量而变化。我们假设怀孕受到先兆流产的影响，但具有可存活的胚胎，由于母体采血时可能潜在的胎盘生长延迟或异常，因此胎盘表达基因PLAC1的mRNA浓度较低。我们研究了10名孕妇妊娠<20周时因先兆流产而入院（先兆流产组）。该研究得到了我们当地伦理委员会的批准，所有患者均获得了知情同意。所有核型异常的胎儿和先兆子痫，早产或足月分娩，子宫病理如肌瘤或畸形，胎盘早产，随访失败以及阴道或宫颈病变的临床检查均能解释阴道出血的胎儿被排除在研究之外。我们还排除了那些因阴道绒毛破坏，凋亡和胚胎死亡而增加母体血液中循环的胎盘细胞和核酸数量的胎儿，以及异常的胎儿核型，胎儿畸形和异常的母体，因为这些妇女发生阴道流血和随后的流产。免疫反应。妊娠后期观察到的胎盘早剥也被排除为可能的胎儿-母亲出血的来源。住院期间，所有妇女均保持完全卧床休息，并进行了常规超声检查和内分泌（β-hCG）评估。我们还研究了66例正常妊娠作为对照。全部...

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