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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Low bias in assayed values of lipoprotein antigens--lipoprotein(a) and apolipoproteins A-I and B--in midday postprandial blood specimens compared with morning fasting specimens.
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Low bias in assayed values of lipoprotein antigens--lipoprotein(a) and apolipoproteins A-I and B--in midday postprandial blood specimens compared with morning fasting specimens.

机译:与餐前空腹标本相比,餐后血液标本中脂蛋白抗原(脂蛋白(a)和载脂蛋白A-I和B)的测定值偏低。

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摘要

Two-hour postprandial specimens have a -14% proportional bias for lipoprotein(a) [Lp(a)], a -0.035 g/L systematic bias for apolipoprotein (apo) A-I, and a -9% proportional bias for apo B, compared with values in 12-h fasting specimens. Although a physiological hemodilution appears to account for a portion of these biases, other major factors must be implicated for Lp(a) and apo B. Even after dilutional effects are controlled for, assayed values of Lp(a) are 11-13% lower, and assayed values of apo B are 8-9% lower, in postprandial specimens than in fasting specimens. Therefore, the time of collection of a blood sample relative to the last meal can significantly affect assayed values of lipoprotein antigens. Further studies are needed to determine whether these observations result from a physiological sequestering of lipoproteins in the postprandial state or from negative interferences affecting the assays of lipoprotein antigens.
机译:餐后两小时的标本中脂蛋白(a)[Lp(a)]的比例偏差为-14%,载脂蛋白(apo)AI的系统偏差为-0.035 g / L,载脂蛋白B的比例偏差为-9%,与12小时禁食标本中的值进行比较。尽管生理性血液稀释似乎是造成这些偏差的部分原因,但Lp(a)和载脂蛋白B也必须涉及其他主要因素。即使在控制了稀释作用后,Lp(a)的测定值也会降低11-13% ,餐后样本中的apo B测定值比空腹样本低8-9%。因此,相对于最后一餐采集血液样品的时间会显着影响脂蛋白抗原的测定值。需要进一步的研究来确定这些观察结果是由于餐后状态下脂蛋白的生理隔离还是由于影响脂蛋白抗原测定的负面干扰而产生的。

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