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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >S100B Protein Concentrations in Amniotic Fluid Are Higher in Monoamniotic than in Diamniotic Twins and Singleton Pregnancies
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S100B Protein Concentrations in Amniotic Fluid Are Higher in Monoamniotic than in Diamniotic Twins and Singleton Pregnancies

机译：羊水中羊水中S100B蛋白的浓度高于双胎和单胎妊娠的羊水。

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S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is located mainly in glial cells (1). It has been suggested that the protein is involved in various cellular functions, but precisely which is still a matter of debate. The protein has been found to act at physiologic concentrations as a cytokine with a neurotrophic role in experimental models, in cell cultures, and in biological fluids such as cord blood, peripheral blood, and urine (1)(2)(3)(4). This hypothesis has been corroborated by measurements of S100B protein in amniotic fluid in the second trimester of pregnancy (5). The present work, following from an earlier study, investigates amniotic fluid S100B concentrations in twins.We performed a case-control study (between January 1998 and June 2002) of 49 women with physiologic twin pregnancies (27 monoamniotic and 22 diamniotic) who underwent amniocentesis to exclude chromosomal abnormalities between the 15th and 18th weeks of gestation (mean, 16.5 weeks). The control group consisted of 490 singleton pregnancies matched for gestational age and weight at sampling and normal neonatal outcome (5 control fetuses for each twin fetus). Appropriate fetal growth was defined by the presence of ultrasonographic signs (when biparietal diameter and abdominal circumference were between the 10th and 90th percentiles) according to the normograms of Campbell and Thoms (6) and by postnatal confirmation of a birth weight between the 10th and 90th percentiles according to our population standards after correction for maternal height, weight, and parity and the sex of the newborns. Exclusion criteria included intrauterine growth retardation; gestational hypertension; diabetes and infections; fetal malformations; chromosomal abnormalities; maternal exposure to alcohol, cocaine, or smoke; perinatal asphyxia; and dystocia.The local ethics committee approved the study protocol, and the parents of the fetuses examined gave …
机译：S100B是存在于中枢神经系统中的EF-hand家族的酸性钙结合蛋白，主要位于神经胶质细胞中（1）。已经提出该蛋白质参与多种细胞功能，但是确切地这仍然是争论的问题。在实验模型，细胞培养物中以及在脐带血，外周血和尿液等生物体液中，发现该蛋白质以生理浓度作为具有神经营养作用的细胞因子起作用（1）（2）（3）（4） ）。在妊娠中期，羊水中S100B蛋白的测定已证实了这一假说（5）。根据先前的研究，本研究调查了双胞胎中羊水S100B的浓度。我们进行了一项病例对照研究（1998年1月至2002年6月之间），对49例生理性双胎孕妇（27例单胎和22例羊膜穿刺）进行了羊膜穿刺术。排除妊娠第15周和第18周之间的染色体异常（平均16.5周）。对照组由490名单胎孕妇组成，这些孕妇根据抽样时的胎龄和体重以及新生儿的正常结局进行了匹配（每个双胞胎胎儿5胎对照胎）。根据坎贝尔和汤姆（6）的规范图，通过超声检查的体征（双顶径和腹围在第10个百分点至第90个百分点之间）以及通过出生后确认出生体重在第10个至第90个之间来定义适当的胎儿生长根据我们的人口标准对百分位数进行校正后，对产妇的身高，体重，均价和新生儿的性别进行校正。排除标准包括子宫内生长迟缓;妊娠高血压;糖尿病和感染;胎儿畸形染色体异常孕妇暴露于酒精，可卡因或烟;围产期窒息;和难产。地方伦理委员会批准了研究方案，接受检查的胎儿的父母给了……

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