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首页> 外文期刊>Critical care : >Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave
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Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave

机译：在热浪中非运动性热相关疾病期间心肌肌钙蛋白I升高

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IntroductionThe prognostic value of cardiac troponin I (cTnI) in patients having a heat-related illness during a heat wave has been poorly documented.MethodsIn a post hoc analysis, we evaluated 514 patients admitted to emergency departments during the August 2003 heat wave in Paris, having a core temperature >38.5°C and who had analysis of cTnI levels. cTnI was considered as normal, moderately elevated (abnormality threshold to 1.5 ng.mL-1), or severely elevated (>1.5 ng.mL-1). Patients were classified according to our previously described risk score (high, intermediate, and low-risk of death).ResultsMean age was 84 ± 12 years, mean body temperature 40.3 ± 1.2°C. cTnI was moderately elevated in 165 (32%) and severely elevated in 97 (19%) patients. One-year survival was significantly decreased in patients with moderate or severe increase in cTnI (24 and 46% vs 58%, all P 120 μmol.L-1, and heart rate >110 bpm. Using Cox regression, only severely elevated cTnI was an independent prognostic factor (hazard ratio 1.93, 95% confidence interval 1.35 to 2.77) when risk score was taken into account. One-year survival was decreased in patients with elevated cTnI only in high risk patients (17 vs 31%, P = 0.04).ConclusionscTnI is frequently elevated in patients with non-exertional heat-related illnesses during a heat wave and is an independent risk factor only in high risk patients where severe increase (>1.5 ng.mL-1) indicates severe myocardial damage.
机译：简介肌钙蛋白I（cTnI）在热浪期间患有热相关疾病的患者的预后价值文献报道很少。方法在事后分析中，我们评估了514例2003年8月在巴黎热浪期间进入急诊科的患者，核心温度> 38.5°C，并分析了cTnI水平。 cTnI被认为是正常，中等升高（异常阈值至1.5 ng.mL-1）或严重升高（> 1.5 ng.mL-1）。根据我们先前描述的风险评分（高，中，低死亡风险）对患者进行分类。结果平均年龄为84±12岁，平均体温为40.3±1.2°C。 165例（32％）中的cTnI升高，而97例（19％）中的cTnI升高。 cTnI中度或重度升高的患者的一年生存率显着降低（24％和46％比58％，所有P 120μmol.L-1，心率> 110 bpm。使用Cox回归分析，仅cTnI严重升高cTnI升高患者的一年生存率仅在高风险患者中降低（17％vs 31％，P = 0.04），这是一个独立的预后因素（危险比1.93，95％置信区间1.35至2.77）。 ）结论scTnI在热浪期间非劳累性热相关疾病的患者中经常升高，并且仅在严重增加（> 1.5 ng.mL-1）表示严重心肌损害的高危患者中才是独立的危险因素。

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