Extracorporeal liver support: a continuing challenge

Ram M Subramanian; John A Kellum

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Extracorporeal liver support: a continuing challenge

机译：体外肝脏支持：持续的挑战

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Given that liver failure continues to pose an enormous clinical challenge, the concept of hepatic dialysis has enjoyed significant interest. In particular, many investigations have examined the therapeutic mechanisms and efficacy of artificial albumin dialysis based systems in acute on chronic liver failure, the results of which have been conflicting. Albumin dialysis systems do not appear to significantly decrease serum concentrations of inflammatory cytokines in severe acute on chronic liver failure. Thus, if these treatments do result in clinical improvement, then other therapeutic mechanisms must be involved.

机译：鉴于肝衰竭继续构成巨大的临床挑战，肝透析的概念引起了极大的兴趣。特别地，许多研究已经检查了基于人工白蛋白透析的系统在慢性肝衰竭急性中的治疗机制和功效，其结果一直存在矛盾。在慢性肝功能衰竭的严重急性发作中，白蛋白透析系统似乎并未显着降低炎性细胞因子的血清浓度。因此，如果这些治疗确实导致临床改善，则必须涉及其他治疗机制。

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《Critical care :》 |2007年第1期|共页
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Ram M Subramanian; John A Kellum;
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机译：体外肝脏支持：持续的挑战
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8. Towards an Artificial Liver Support, Detoxifying Enzymes Bound to Artificial Carriers for an Extracorporeal Application. Proceedings of the International Conference on Bioengineering Held at Cape Town, April, 1977 [R] . Brunner, G. , Loesgen, H. 1979

机译：朝向人工肝支持，解毒结合人工载体的酶用于体外应用。生物工程国际会议论文集于1977年4月在开普敦召开

Extracorporeal liver support: a continuing challenge

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