Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen

Ross Davenport

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Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen

机译：严重创伤性出血后的凝固性疾病：溶解，致死和缺乏纤维蛋白原

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Trauma-induced coagulopathy (TIC) is present soon after injury and is associated with increased transfusion requirements and worse outcomes. The pathophysiological mechanisms, which result in the widespread derangements of hemostasis following major trauma hemorrhage, are as yet not fully defined. Profound activation of fibrinolytic pathways and fibrinogen depletion appear to be fundamental processes in the development of TIC and offer potential therapeutic targets. Collaborative and multi-disciplinary scientific study is thus a research priority in order to characterize the primary drivers of TIC and develop targeted and efficacious treatment strategies.

机译：创伤后不久出现创伤性凝血病（TIC），与输血需求增加和预后差有关。导致严重创伤性出血后止血的广泛紊乱的病理生理机制尚未完全阐明。纤维蛋白溶解途径的深刻活化和纤维蛋白原的消耗似乎是TIC发展的基本过程，并提供了潜在的治疗靶点。因此，协作和多学科科学研究是研究的重点，目的是表征TIC的主要驱动因素并制定有针对性的有效治疗策略。

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《Critical care :》 |2014年第3期|共页
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Ross Davenport;
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中图分类护理学;
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机译：创伤中纤维蛋白原的耗竭：早期，容易评估且对创伤引起的凝血病至关重要
2. How do external factors contribute to the hypocoagulative state in trauma-induced coagulopathy? – In vitro analysis of the lethal triad in trauma [J] . Michael Caspers, Nadine Sch?fer, Matthias Fr?hlich, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . 2018,第1期

机译：外部因素如何导致创伤性凝血病的低凝状态？ –创伤中致命三合会的体外分析
3. Current strategies for hemostatic control in acute trauma hemorrhage and trauma-induced coagulopathy [J] . Caspers Michael, Maegele Marc, Froehlich Matthias Expert review of hematology . 2018,第7a12期

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4. Reversing coagulopathy and internal hemorrhage with functionalized nanoparticles [C] . Damien Kudela, Anna May-Masnou, Stephanie A. Smith, Annual NSTI nanotechnology conference and expo . 2013

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5. Reversal of Warfarin-Associated Coagulopathy: Prothrombin Complex Concentrates Versus Fresh Frozen Plasma in Elderly Patients Presenting with Intracranial Hemorrhage [D] . Lumas, Shunella Grace. 2020

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6. Coagulopathy following major trauma hemorrhage: lytic lethal and a lack of fibrinogen [O] . Ross Davenport 2014

机译：严重创伤性出血后的凝固性疾病：溶解致死和缺乏纤维蛋白原
7. Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen [O] . Ross Davenport 2014

机译：严重创伤性出血后的凝固性疾病：溶解，致死和缺乏纤维蛋白原

Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen

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