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Advances in the support of respiratory failure: putting all the evidence together

机译：支持呼吸衰竭的研究进展：将所有证据汇总在一起

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Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy and outcome, and the stage and severity of the disease process may determine the patient's vulnerability as well as an intervention's value. Reducing oxygen consumption and ventilatory demands are key to a successful strategy for respiratory support of acute respiratory distress syndrome. Results from major clinical trials can be understood against the background of the complex physiology of ventilator-induced lung injury.
机译：最近在了解如何最好地完成急性肺损伤患者的安全和有效通气方面取得了可观的进展。机械和非机械因素是导致呼吸机相关性肺损伤的原因。干预时机有助于确定治疗效果和结果，疾病过程的阶段和严重性可以确定患者的脆弱性以及干预措施的价值。减少氧气消耗和通风需求是成功实施急性呼吸窘迫综合征呼吸支持策略的关键。在呼吸机诱发的肺损伤的复杂生理学背景下，可以理解主要临床试验的结果。

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