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Physiology versus evidence-based guidance for critical care practice

机译：重症监护实践的生理学与循证指南

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Evidence based medicine is an attempt to optimize the medical decision process through methods primarily based on evidence coming from meta-analyses, systematic reviews, and randomized controlled trials ("evidence-based medicine"), rather than on "clinical judgment" alone. The randomized trials are the cornerstones of this process. However, the randomized trials are just a method to prove or disprove a given hypothesis, which, in turn, derives from a general observation of the reality (premises or theories). In this paper we will examine some of the most recent randomized trials performed in Intensive Care, analyzing their premises, hypothesis and outcome. It is quite evident that when the premises are wrong or too vague the unavoidable consequences will be a negative outcome. We should pay when designing the trial an equal attention in defining premises and hypothesis that we pay for the trial conduction.
机译：循证医学是一种尝试通过主要基于荟萃分析，系统评价和随机对照试验（“循证医学”）得出的证据而不是仅基于“临床判断”的方法来优化医学决策过程的尝试。随机试验是该过程的基石。但是，随机试验只是证明或反证给定假设的一种方法，而该假设又是从对现实（前提或理论）的一般观察得出的。在本文中，我们将研究在重症监护室进行的一些最新随机试验，分析其前提，假设和结果。很明显，当前提错误或过于模糊时，不可避免的后果将是负面结果。在设计试验时，我们应该在定义前提和假设时给予同等的关注，这些前提和假设是我们为试验进行支付的。

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